A study of Liver function and Renal function tests in chronic alcoholics at a tertiary health care centre

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A study of Liver function and Renal function tests in chronic alcoholics at a tertiary health care centre

Journal Title: Medpulse International Journal of Biochemistry - Year 2018, Vol 8, Issue 2

Abstract

Background: More than 3 million people died as a result of harmful use of alcohol in 2016, according a report released by the World Health Organization (WHO). This represents 1 in 20 deaths. More than three quarters of these deaths were among men. In recent years, conventional biochemical markers and potential ones have aroused the interest of researchers to study the damages caused by ethanol in liver. There is evidence that chronic alcohol consumption may cause direct damage to the kidneys. It may also indirectly alter renal function by elevating blood pressure, inducing electrolyte imbalances and inducing hyperuricaemia. Objective: To study Liver function tests and Renal function tests in chronic alcoholic patients. Methods: This is a descriptive observational study conducted among 100 confirmed cases of alcoholism. Alcoholic liver disease was diagnosed in patients with a history of significant alcohol intake for a minimum period of 10 years, physical signs of liver disease and supportive laboratory data. Results: In our study, majority were 41-50 years age group. i.e. 35 (35%). Mean age of study subjects was 44.1± 11.2 years. LFT revealed total Bilirubin level as 4.98±1.08, Direct bilirubin 3.54±2.65, ALT 50.3±18.2, AST was 121.1±43, ALP 125±41.1, GGT 52.2±15.43 and AST/ALT ratio was 2.4±0.63. RFT revealed that Blood urea level as measured to be 67.6±12.2, whereas Serum creatinine value was found to be 2.1±0.51. Conclusion: In our study Liver and Renal parameters were deranged. Excessive alcohol consumption can have profound negative effects on the kidneys and their function in maintaining the body’s fluid, electrolyte, and acid-base balance, leaving alcoholic people vulnerable to a host of Liver and kidney related health problems.

Authors and Affiliations

Mohammad Rafi, Vijay Mohan M

Keywords

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EP ID EP442167
DOI 10.26611/10028212
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