Comparison of Survival And Prognostic Factors In Patients With Carcinosarcoma And Non Endometrioid Carcinoma of The Uterine Corpus
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 9
Abstract
Carcinosarcome (CS) of the uterine corpus (malignant mixed Müllerian tumor) is an uncommon and extremely aggressive histologic subtype of endometrial carcinoma. Treated like the non endometrioid carcinoma (NEC), this study aims to compare survival rates between CS and NEC and to identify histopronostic risk factors influencing their outcomes.This was a retrospective study including 50 women treated over a period of 17 years (1998-2015). We analyzed difference in clinical and survival characteristics between the two types of endometrial cancer CS (n=27) and the control group of NEC (n=23). Disease specific survival (DSS) and disease free survival (DFS) curves were performed.The stage distribution was: stage IA (30%), stage IB (12%), stage II (16%), stage IIIA (2%), stage IIIB (2%), stage IIIC1 (12%), stage IIIC2 (8%) and stage IV (18%). Median DFS was 19 and 22 months for NEC and CS, respectively. 5-years DFS were 48.5% in NEC and 48.7% in CS (p=0.570). Median DSS was 35 months for NEC and 21 months for CS. The 1, 2 and 5-years DSS were 84%, 65% and 40.6% for NEC and 84.4%, 48%, 34.4% for CS (p=0.938). Univariate analysis demonstrated a significant correlation between elder age (p=0.03), presence of LVSI (p=0.016) and the DSS. Multivariate analysis found that the LVSI was the only independent predictive factor of DSS (p=0.022; HR=0.355; CI [0.147; 0.859]. Our study emphasizes the similarity of survival rates of CS and NEC. It also underscore the importance of LVSI as an independent prognostic factor of DSS.
Authors and Affiliations
Ines Ben Safta, Olfa Jaidane, Houyem Mansouri, Raoudha Doghri, Azza Chabchoub, Jamel Ben Hassouna, Khaled Rahal
Keywords
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