Comparison of the efficacy of intrathecal buprenorphine and clonidine as adjuvants to bupivacaine for postoperative analgesia and abdominal muscle relaxation in patients of abdominal hysterectomy
Journal Title: Medpulse International Journal of Anesthesiology - Year 2019, Vol 9, Issue 3
Abstract
Background and Aims: Various adjuvants have been used with local anesthetics in spinal anesthesia to provide adequate analgesia and muscle relaxation. The aim of this study was to evaluate and compare the two intrathecal adjuvants, buprenorphine and clonidine for postoperative analgesia and intraoperative abdominal muscle relaxation in patients undergoing abdominal hysterectomy. Methods: One hundred and fifty adult patients undergoing elective abdominal hysterectomy under spinal anaesthesia were randomly divided into two groups. Group B received 60 μg buprenorphine and Group C received 30 μg clonidine with 3.4 ml of 0.5% hyperbaric bupivacaine. Both groups were evaluated and compared for duration of postoperative analgesia, abdominal relaxation and incidence of adverse effects. Data was analysed with Z- test. Results: Duration of postoperative analgesia was more prolonged in Group C (361.6 ± 41.81 min-Group B, 416 ± 50.61 min-Group C). Abdominal relaxation was better in Group C [P = 0.0089]. Onset of sensory (6.08 ± 1.22 min- Group B, 5.88 ± 1.42 min-Group C) and motor (9.93 ± 2.39 min-Group B, 10.33 ± 2.88 min-Group C) blocks were comparable. Duration of sensory (304.8 ± 42.72 min-Group B, 366.4 ± 44.46 min-Group C) and motor (219.2 ± 26.08 min-Group B, 306 ± 35.9 min-Group C) blocks were more prolonged in Group C. The incidence of hypotension was higher in Group C [P = 0.000]. Conclusion: Intrathecal clonidine as an adjuvant to bupivacaine provides betterpostoperative analgesia and abdominal relaxation than buprenorphine in patients undergoing abdominal hysterectomy under spinal anaesthesia, but was associated with higher incidence of hypotension.
Authors and Affiliations
Prashant Lomate, Jyotsna Paranjpe, Shilpa Gaikwad
Keywords
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- EP ID EP521230
- DOI 10.26611/10159310
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