Comparison of the species of dermatophytes isolated from patients responding and not responding to terbinafine treatment
Journal Title: INTERNATIONAL JOURNAL OF RECENT TRENDS IN SCIENCE AND TECHNOLOGY - Year 2017, Vol 22, Issue 2
Abstract
Background: Trichophyton rubrum and Trichophyton mentagrophytes, which cause infections of skin and nails, are two of the most frequently isolated dermatophytes. Terbinafine is widely used in therapy of dermatophyte infection. Presently clinicians are facing lack of clinical response to terbinafine in some patients. Hence, clinical response to treatment was noted and data was compared between those responding and not responding to terbinafine treatment. Material and Methods: A total of the 187 cases were clinically diagnosed as tinea corporis.The skin scrapings were collected two times from each patient, before instituting treatment and one week after completion of terbinafine treatment in clinically resistant cases. A total of 123 patients were responsive to clinical antifungal treatment which were grouped as the Responsive Group; and 64 patients were clinically resistant to antifungal treatment (Resistant Group). Results: In all 64/187 (34.2%) patients with T. rubrum and T. mentagrophytes infections were clinically non responsive to treatment with terbinafine. Patients had persistent lesions and all these were positive by direct microscopy or culture or both in their post treatment clinical specimens. Discussion: The clinical resistance of dermatophyte isolates may involve more than one mechanisms which are both fungus related and host related. The low diversity of antimycotic drugs may indicate existence of differences between pathogen and host yet unexplored which maybe used in new drug development.
Authors and Affiliations
Neha Sharma, Uma Tendolkar
Keywords
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