Comparison of therapeutic effects of transcatheter aortic valve replacement surgery on patients with severe aortic valve stenosis with different ejection fractions
Journal Title: Chinese Journal of Clinical Research - Year 2024, Vol 37, Issue 6
Abstract
Objective To investigate the efficacy of transcatheter aortic valve replacement (TAVR) in treating patients with severe aortic stenosis (AS) of different levels of cardiac function. Methods A retrospective analysis was conducted on clinical data of 72 patients who underwent TAVR for severe AS at the Xinjiang Uygur Autonomous Region People's Hospital from September 2016 to July 2022. Patients with a left ventricular ejection fraction (LVEF) ≥50% were included in the preserved ejection fraction group (group A, n =44), while those with LVEF＜50% were included in the reduced ejection fraction group (group B, n =28). The effective orifice area (EOA), mean transvalvular pressure gradient, and left ventricular remodeling (LVR) were observed in both groups preoperatively and postoperatively at 1 day, 3 months, and 12 months. The 6-minute walk distance (6-MWD) was measured preoperatively and postoperatively at 3 months and 12 months for both groups. All patients were followed up to one year postoperatively to observe the readmission rate due to heart failure. Results Both groups showed significant improvement in EOA and mean transvalvular pressure gradient on the first postoperative day, which remained stable thereafter. On the first postoperative day, LVR indicators ［left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD), left ventricular posterior wall thickness (LVPWT), LVEF］ improved significantly in both groups compared to preoperative values ( P ＜0.05). During subsequent follow-ups, group A maintained a relatively stable state, while group B continued to show LVR until the end of the follow-up period. The 6-MWD at 3 months postoperatively improved significantly in both groups compared to preoperative values and remained stable thereafter. The readmission rate due to heart failure within one year between group A and group B showed no statistically significant difference (4.54% vs 21.43%, χ 2 =3.380, P =0.066). Conclusion TAVR can effectively alleviate obstruction of the left ventricular outflow tract in patients with severe AS and different ejection fractions, improve exercise tolerance, and promote left ventricular reverse remodeling. For patients with preserved ejection fraction and severe AS, intervention should be carried out as early as possible.
Authors and Affiliations
KONG Can, GUO Zitong, Zulipiyem Xier, FAN Hao, PENG Hui
Keywords
Related Articles
- EP ID EP738334
- DOI 10.13429/j.cnki.cjcr.2024.06.006
- Views 36
- Downloads 0
The predictive value of whole brain CT perfusion imaging and serum MMP-9 level in hemorrhagic transformation after acute cerebral infarction
"<b>Objective</b> To explore the value of whole brain CT perfusion (CTP) imaging parameters and serum MMP-9 level in predicting hemorrhagic transformation (HT) after endovascular therapy of acute cerebral infarction (ACI...
Correlation between triglyceride-glucose index and atherosclerosis in type 2 diabetes mellitus
Objective To investigate the the clinical application of triglyceride-glucose (TyG) index and its correlation with atherosclerosis in patients with type 2 diabetes mellitus (T2DM). Methods From January 2020 to December...
Efficacy of bronchoscopic ablation combined with local injection of endostatin in advanced non-small cell lung cancer patients with intratracheal metastasis
Objective To explore the efficacy and safety of bronchoscopic ablation combined with local injection of endostatin in patients with intratracheal metastasis of advanced non-small cell lung cancer(NSCLC). Methods A retr...
Current application of in-hospital informatized glucose monitoring system in Jiangsu
"<b>Objective</b> To investigate the application of in-hospital informatized blood glucose monitoring system (IGMS) in Jiangsu and the satisfaction of medical staff to use IGMS. <b>Methods</b> From August 2021 to July...
Evaluation of plasma atherogenic index on short-term prognosis of intravascular interventional therapy in patients with acute ischemic stroke
Objective To explore the role of plasma atherosclerotic index (AIP) in evaluating the short-term prognosis of endovascular intervention in acute ischemic stroke (AIS) patients of different age groups. Methods From Janu...