COMPARISON OF VAGINAL AND ORAL DOSES OF MISOPROSTOL FOR INDUCTION OF LABOUR IN POSTDATED PREGNANCIES
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 94
Abstract
BACKGROUND Considering maternal complications, it is preferred to induce labour after 40 weeks. Induction of labour is the artificial initiation of labour before its spontaneous onset for the purpose of delivery of the foetoplacental unit using mechanical or pharmacologic methods. Aim- The aim of this study was to compare 50 micrograms of oral misoprostol with 25 micrograms of vaginal misoprostol for induction of labour in postdated pregnancies. MATERIALS AND METHODS This is a randomised controlled trial conducted on 68 uncomplicated postdated pregnant women who were admitted to labour ward of King George Hospital, Visakhapatnam, Andhra Pradesh in the months of June, July and August in 2017. Sample size was taken conveniently. 68 pregnant women who were included in the study for induction were divided into either of the two groups and allocation of groups done by simple randomised lot method. In group A, 50 μg of oral misoprostol and in group B 25 μg of vaginal misoprostol was used for inducing labour. Gestational age, parity, Induction starting time with misoprostol, initiation of uterine contractions, induction delivery interval, caesarean section and vaginal delivery rate and other variables including tachysystole, improvement in Bishop score, foetal outcome were recorded on the checklist. The results were interpreted as mean and standard deviation and chi-square test was done to know the statistical significance using SPSS version 15.0. RESULTS In group A, 33 cases were included and in group B 35 cases were included. All women were between 20-25 years of age. The mean number of doses of 50 micrograms oral misoprostol that were required for induction of labour was 1.89 ± 0.769 which was significantly less compared to the mean number of doses required for induction in the vaginal group i.e. 2.94 ± 1.11, with P- value 0.000. 42.4% of cases in Group A and 80.05% of cases in Group B required augmentation with oxytocin. The difference was statistically significant, with P-value 0.001. CONCLUSION In terms of labour induction and maternal outcomes in the postdated pregnant women, oral misoprostol 50 μg is more useful than vaginal misoprostol 25 μg. In mothers receiving oral misoprostol, induction delivery interval and the number of doses were less.
Authors and Affiliations
Shailaja Pinjala, Tejaswi P. B
Keywords
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- EP ID EP279901
- DOI 10.14260/jemds/2017/1478
- Views 70
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