Comparisonbetweenbepotastinebesilate 1.5% eye drop versus olopatadine hydrochloride 0.2% eye drop in cases of allergic conjunctivitis
Journal Title: Medpulse International Journal of Ophthalmology - Year 2018, Vol 8, Issue 2
Abstract
Background: Allergic conjunctivitis is an increasingly prevalent allergic reaction having clinical gravity similar to asthma and allergic rhinitis. Aims and Objectives: To study Comparison between bepotastinebesilate 1.5% eye drop versus olopatadine hydrochloride 0.2% eye drop in cases of allergic conjunctivitis. Methodology:fortyconsecutive patients presenting from March 2018 to July 2018 in Eye OPD at Saraswathi institute of medical sciences Hapur, with symptoms of ocular itching associated with allergic conjunctivitis a were enrolled in this study. Here, Group A (1st drug B and 2nd drug O) (n=20), Group B(1st drug O and 2nd drugB ) (n=20), where Bepotastinebesilate 1.5% eye drop, O Olopatadine hydrochloride 0.2% eye drop. 1stvisit done after 1st day of starting the drug, 2nd visit (day 16)after use of first medication,3rd Visit (day 39)after use of second medication. The itching symptoms and all Ocular allergy symptomswere graded on 5points scale. The statistical analysis done by unpaired t-test and calculated by SPSS 19 version software.Result:the majority of the patient were in the age group of 40-50 i.e. 60% followed by 30-40-17.5%, 20-30 were 12.5%, 50-60 were 10%. The mean age was (Mean ±SD) 41.68 ± 8.51. The majority of the patients were females 65% and males were 35%. At first visit the symptoms itching were comparable with each other as Ocular itchinggrading on 5 point scale was 4.2 ± 0.52and4.35 ± 0.49 in group A and B respectively(t=0.94 df=38,p>0.05) ; on2nd visit (day 16)after use of first medication the relief score in ocular itching was significantly higherin Group A i.e. 3.9± 0.79 versus2.85 ± 0.67 in group B (t=4.9 df=38,P<0.0001), 3rd Visit (day 39)after use of second medication the score was significantly higher in Group B i.e.3.7±0.47 as compared to 2.65 ±0.81in group A(t=5.0 df=38, P<0.0001). At 2nd visit (day 16)after use of first medication the relief scorein all ocular allergy symptoms was significantly higher in Group A i.e. 3.55± 0.69 as compared to2.65± 0.75 in group B (t=5.23,df=38,p<0.0001) , at 3rd Visit (day 39)after use of second medication the score was significantly higher in Group B i.e. 3.2±0.70 as compared to 2.3±0.73in group A(t=4.92 ,df=38,p<0.0001).Conclusion: at the baseline both the drugs were comparable with each other, at second visit the score was variablebut at the end the response with respect to score and patients preference the bepotastinebesilate 1.5% was found superior to olopatadine hydrochloride 0.2% with respect to treatment of allergic conjunctivitis.
Authors and Affiliations
Prerana Agarwal, S D Tayal
Keywords
Related Articles
- EP ID EP460623
- DOI -
- Views 79
- Downloads 0
Incidence of fungal corneal ulcer in stick injuries
Background: This study was undertaken to determine the risk factors which predisposes to fungal keratitis, especially the significant epidemiological factors. Materials and Method: This was a prospective study conducted...
Study of rise of intraocular pressure and effect onvisual outcome in patients receiving intravitreal triamcinolone acetonide in macular disorders
Background: Macular edema represents a final common pathway response of the retina to a variety of possible insults. Intravitreal triamcinolone acetonide is commonly used in treatment of macular edema and hence complicat...
Comparative study of using fibrin glue and sutures in pterigyum excision with conjunctival autograft in tertiary care center
Background: Pterygium is a fibrovascular, wing shaped encroachment of the conjunctiva on to the cornea. The prevalence rates of pterygia range from 0.7 to 31% among different populations and are also influenced by age, r...
A study on keratometry, axial length and IOL power among patients undergoing cataract surgery
For ocular examination there are three diagnostic aids namely, A-scan B-scan and M-scan with these techniques, several different systems for ultrasonically evaluating patients have been evolved. Independently either only...
Aggressive orbital Burkitt’s lymphoma with rapid onset proptosis
Burkitt’s lymphoma is rare B cell monoclonal malignant lymphoma with short doubling time (less than 3 days) occurring due to deregulation of c-myc oncogene. Most Burkitt’s lymphomas (80% to 90%) carry a translocation of...