Comparisonbetweenbepotastinebesilate 1.5% eye drop versus olopatadine hydrochloride 0.2% eye drop in cases of allergic conjunctivitis
Journal Title: Medpulse International Journal of Ophthalmology - Year 2018, Vol 8, Issue 2
Abstract
Background: Allergic conjunctivitis is an increasingly prevalent allergic reaction having clinical gravity similar to asthma and allergic rhinitis. Aims and Objectives: To study Comparison between bepotastinebesilate 1.5% eye drop versus olopatadine hydrochloride 0.2% eye drop in cases of allergic conjunctivitis. Methodology:fortyconsecutive patients presenting from March 2018 to July 2018 in Eye OPD at Saraswathi institute of medical sciences Hapur, with symptoms of ocular itching associated with allergic conjunctivitis a were enrolled in this study. Here, Group A (1st drug B and 2nd drug O) (n=20), Group B(1st drug O and 2nd drugB ) (n=20), where Bepotastinebesilate 1.5% eye drop, O Olopatadine hydrochloride 0.2% eye drop. 1stvisit done after 1st day of starting the drug, 2nd visit (day 16)after use of first medication,3rd Visit (day 39)after use of second medication. The itching symptoms and all Ocular allergy symptomswere graded on 5points scale. The statistical analysis done by unpaired t-test and calculated by SPSS 19 version software.Result:the majority of the patient were in the age group of 40-50 i.e. 60% followed by 30-40-17.5%, 20-30 were 12.5%, 50-60 were 10%. The mean age was (Mean ±SD) 41.68 ± 8.51. The majority of the patients were females 65% and males were 35%. At first visit the symptoms itching were comparable with each other as Ocular itchinggrading on 5 point scale was 4.2 ± 0.52and4.35 ± 0.49 in group A and B respectively(t=0.94 df=38,p>0.05) ; on2nd visit (day 16)after use of first medication the relief score in ocular itching was significantly higherin Group A i.e. 3.9± 0.79 versus2.85 ± 0.67 in group B (t=4.9 df=38,P<0.0001), 3rd Visit (day 39)after use of second medication the score was significantly higher in Group B i.e.3.7±0.47 as compared to 2.65 ±0.81in group A(t=5.0 df=38, P<0.0001). At 2nd visit (day 16)after use of first medication the relief scorein all ocular allergy symptoms was significantly higher in Group A i.e. 3.55± 0.69 as compared to2.65± 0.75 in group B (t=5.23,df=38,p<0.0001) , at 3rd Visit (day 39)after use of second medication the score was significantly higher in Group B i.e. 3.2±0.70 as compared to 2.3±0.73in group A(t=4.92 ,df=38,p<0.0001).Conclusion: at the baseline both the drugs were comparable with each other, at second visit the score was variablebut at the end the response with respect to score and patients preference the bepotastinebesilate 1.5% was found superior to olopatadine hydrochloride 0.2% with respect to treatment of allergic conjunctivitis.
Authors and Affiliations
Prerana Agarwal, S D Tayal
Keywords
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