COMPT (CATHECOL O METHYL TRANSFERASE) GENE AS GENETIC RISK FACTOR FOR JAVANESE SCHIZOPHRENIA
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2016, Vol 8, Issue 4
Abstract
Objective: Several genes were suspected as a genetic marker of schizophrenia disease. This research was done to investigate the influence of Cathecol O-methyl transferase (COMPT) gene polymorphism toward incidence of schizophrenia on Javanese people.Methods: There were two groups. The first group was Javanese schizophrenia patients, and the second group was not schizophrenia patients (control group). Each group contains 25 patients. The sample was taken from blood vein patients. Deoxyribonucleic acid (DNA) isolation was done using DNA isolation kit (Qiagen®). The method of genotyping was carried out by restriction fragment length polymorphism polymerase chain reaction (RFLP PCR) followed by digestion by Hin1 II enzyme.Results: The results of this study showed that 64 % HH allele and 36 % LH allele of COMPT gene (G21881A) were found on Javanese schizophrenia while 76 % HH and 24 % LH allele were found on the control group. Odd ratio (OR) LH allele was 1,781 and OR HH allele was 0,561Conclusion: The presence of LH allele of COMPT gene A1625G increases the risk of schizophrenia on Javanese people. The COMPT gene (G21881A) is a genetic risk factor for Schizophrenia disease on Javanese people.Keywords: Schizophrenia, Javanese, COMPT gene
Authors and Affiliations
Em Sutrisna, Ratna Yuliani
Keywords
Related Articles
- EP ID EP577750
- DOI -
- Views 42
- Downloads 0
EFFECT OF SODIUM NITRITE EXPOSURE ON THE IMMUNE RESPONSES AGAINST OF RIFT VALLEY FEVER VACCINE IN MICE
Objective: Daily exposure to food preservatives constitutes a major crisis to children especially during vaccination so; the aim of the study is to assess the effect of sodium nitrite on the immune responses against Rift...
ANALYTICAL QUALITY BY DESIGN APPROACH FOR DEVELOPMENT OF UV SPECTROPHOTOMETRIC METHODS IN THE ESTIMATION OF TROSPIUM CHLORIDE FROM CAPSULE DOSAGE FORM
Objective: The aim of present work is to develop and validate two spectrophotometric methods for trospium chloride estimation in capsule dosage form using Analytical Quality by Design (QbD) approach as per ICH Q8 (R2) gu...
ANTIDIABETIC AND ANTIHYPERLIPIDEMIC EFFECTS OF METHANOLIC EXTRACT OF CITRULLUS LANATUS SEEDS IN RATS
Objective: Aim of the present study is to evaluate the antidiabetic and antihyperlipidemic effect of methanolic extract of Citrullus lanatus seeds (MECL) in streptozotocin (STZ) induced diabetic rats.Methods: Diabetes wa...
FORMULATION AND EVALUATION OF MELOXICAM LIQUISOLID COMPACT
Objective: The aim of the present research was to improve dissolution of poorly soluble meloxicam a BCS (Biopharmaceutical Classification System) Class-II drug by utilizing liquisolid technique. Different liquisolid (LS)...
ASSESSMENT OF GENETIC DIVERSITY IN TINOSPORA CORDIFOLIA BY INTER SIMPLE SEQUENCE REPEATS (ISSR) AND EXPRESSED SEQUENCE TAGGED- SIMPLE SEQUENCE REPEATS (EST-SSR)
Objective: In this study, assessment of genetic diversity was carried out using two kinds of molecular markers: Inter-Simple Sequence Repeats (ISSR) and Expressed Sequence Tag Simple Sequence Repeats (EST-SSR) in T. cord...