Congenital Hyperinsulinism: the Possibilities of Modern Diagnosis and Treatment
Journal Title: Міжнародний ендокринологічний журнал - Year 2015, Vol 3, Issue 67
Abstract
Congenital hyperinsulinism (CHI) — one of the main causes underlying the development of persistent hypoglycemic conditions in childhood. The article presents the experience of diagnosis and treatment in patients with CHI. We have examined 7 children diagnosed with СHI aged 1 month to 1.5 years. For diagnosing CHI, we have used routine clinical and laboratory investigations, as well as molecular genetic and instrumental diagnostics (18F-DOPA positron emission tomography). Molecular genetic testing confirmed the diagnosis of CHI in 6 children. All 7 children with CHI had various resistance to conservative treatment, had a different degree of psychomotor development and seizures. Of them, 6 children underwent surgery with achievement of normoglycemia. Genetic testing and 18F-DOPA positron emission tomography should be carried out in all children with hypoglycemia and increased or normal levels of C-peptide and insulin to clarify the type of CHI. Further development of genetic diagnostics is necessary to find new CHI genes. Surgical treatment may be a treatment of choice in children with CHI, particularly in its focal form.
Authors and Affiliations
Ye. V. Hloba
Experience of Modern Premixed Insulin Use in Treatment of Diabetes Mellitus
No abstract
Results of epidemiological studies on the prevalence of iodine deficiency disorders in the Republic of Uzbekistan
Background. In spite of the works performed against iodine deficiency disorders (IDD), they still remain severe in Uzbekistan. The purpose of the study was to investigate the dynamics of the prevalence of IDD among the p...
Some aspects concerning abdominal obesity diagnosis in city population of Ukraine
Background. Optimized preventive approaches concerning the development of comorbidity in the patients with overweight of various degree is a topical issue of medical science. Efficiency of such approaches depends on a wh...
Influence of ursodeoxycholic acid on insulin resistance in patients with metabolic syndrome
The lecture describes the mechanisms of non-alcoholic fatty liver disease in patients with metabolic syndrome. A comprehensive treatment with the use of ursodeoxycholic acid has reduced the severity of hepatic steatosis,...
Comparison of efficiency of omega-3 polyunsaturated fatty acids, statins and their combination on lipids parameters, vascular-thrombocyte homeostasis and heart rate variability parameters in patients with type 2 diabetes mellitus and cardiovascular autonomic neuropathy
Background. The analysis of combined omega-3 polyunsaturated fatty acids (ω-3 PUFAs) and statins prescription to patients with cardiac autonomic neuropathy (CAN) and type 2 diabetes mellitus (T2DM) is of great interest....