Consanguinity, inbreeding and genetic load in salis: A sub divided population of Andhra Pradesh, South India
Journal Title: Asian Pacific Journal of Health Sciences - Year 2017, Vol 4, Issue 1
Abstract
Aims and Objectives: The objective of the present study is to assess the genetic composition of the two subgroups of Salis and the extent of genetic differentiation among them with the help of various demographic and genetic variables. Materials and Methods: A total of 520 couples belonging to two sub-groups namely, Padmasalis and Pattusalis residing in and around Visakhapatnam and Vizianagaram of Andhra Pradesh were included in this study. Demographic data pertaining to consanguinity and reproductive histories were obtained. Statistical analysis was done using SPSS v 19 software. Results: Out of 520 married couples, 180 women had practiced consanguineous marriages (34.62%) and 340 women had adapted to non-consanguineous (65.38%) marriages. The overall consanguinity is more among the Padmasalis (36.98%) than among the Pattusalis (32.16%). However, the difference between the two groups is not statistically significant. The coefficient values for autosomal genes is higher in Padmasalis (0.0354) than the Pattusalis (0.0279). Likewise, the coefficient values for sex -linked genes is higher in Padmasalis (0.0340) than the Pattusalis (0.0319). In the present study population the inbreeding load ( B) obtained for Pattusalis was positive (0.8850) but in Padmasalis it was negative ( -2.5714) indicating an increase in survival of individuals with increased homozygosity. The random load (A) in Pattusalis was 1.5944 and in Padmasalis it was 1.9290. The pooled data of Salis recorded a negative B value indicating an increase of fitness of offspring in comparison to the fitness of their parental generations. Conclusion: The frequency of consanguinity was found to be high in Salis. The findings are in concurrence with the earlier reports of high prevalence of consanguineous marriages in South India. Female education, socio-economic status and parental decisions in marriages may be the reasons.
Authors and Affiliations
P. Mohan Rao
Keywords
Related Articles
- EP ID EP525310
- DOI 10.21276/apjhs.2017.4.1.29
- Views 189
- Downloads 0
Stability Indicating Simultaneous Validation of Aspirin, Clopidogrel and Rosuvastatin with Forced Degradation Behavior Study by RP-HPLC in Pharmaceutical Dosage Form
For simultaneous validating anassay of Aspirin, Clopidogrel and Rosuvastatin in Capsule Dosage Form, a simple, precise and accurate RP-HPLC method has been developed. Isocratic RP-HPLC process was established on BDS hype...
Evaluation of work stress in health care receptionists: A cross sectional study
Back ground: Receptionists’ work is complex, demanding and intense, involving a high level of commitment to patients, colleagues, and the practice. Aims and objectives: This study was aimed at an evaluation of stress le...
Awareness study on the availability, prevalence and knowledge in use of contraceptives among female adolescent pupils in Ndola, Zambia
Adolescents in Zambia face numerous sexual and reproductive health risks, stemming from early and unprotected sexual activities. The engagement in these casual sex practices has contributed to high incidences of abortion...
Effects of Vitamins in Augmentation of Malaria Treatment: A review
Malaria continues to cause significant morbidity and mortality in several settings in the tropical regions of the world despite the availability of efficacious and potent antimalarial drugs. This has led to an increased...
A cross sectional study on infection control practices among mothers attending immunization clinic at a teaching hospital in Haryana
Introduction: Mother’s hand washing practices, immunization awareness and early initiation of breast feeding are important steps to reduce neonatal and infant morbidity & mortality. Still these are not routinely practice...