CONSEQUENCES OF DOPAMINERGIC AGONIST ASSOCIATED WITH BDNF TREATMENT ON BEHAVIORAL ALTERATIONS AND CYTOLOGICAL CHANGES IN AN EXPERIMENTAL MODEL OF PARKINSON DISEASE DUE TO MANGANESE EXPOSURE.
Journal Title: International Journal of Advanced Research (IJAR) - Year 2018, Vol 6, Issue 2
Abstract
Parkinson disease (PD) is characterized by dopaminergic (DA) neuronal loss and motor alterations; in this way, an effective therapy should protect and regenerate the DA neurons and striatal innervation. Brain-derived neurotrophic factor (BDNF) is a cell survival mediator and can improve neuronal death, and the activation of DA D3 receptors seems to protect the DA neurons. Thus, there is a synergistic relationship between BDNF and D3 receptors; which would be a neuroprotective therapy. PD animal models, although exhibit some of the features, no one mimics the alterations observed in the disease. PD-Manganese (Mn) inhalation model was used in this report since it is bilateral, non-invasive and progressive. The rats were exposed to Mn 1 hour 3 times a week, and the motor tests were conducted to measure the performance as well as the progressive damage at 3 and 6 months of exposure. Subsequently, the D3 agonist treatment (7-OH-DPAT) and BDNF gene transfection to DA neurons were co-administered, and then we evaluated its effect measuring the animals\\\\\\\' performance, and if the recovery was associated with DA neuronal and striatal dendritic spines preservation. The results showed that the animals presented PD-like motor alterations, and great DA neurons and striatal dendritic spines loss. The behavior recovery was associated with the DA neurons recuperation and with the number of dendritic spines of the striatal neurons. Thus, the BDNF overexpression in DA neurons related to the D3 receptors activation seems to be a promising approach for restoring motor alterations and DA neurons in PD.
Authors and Affiliations
M. Teresa Ibarra- Gutiearrez, Veronica Anaya- Martinez
Keywords
Related Articles
- EP ID EP278055
- DOI 10.21474/IJAR01/6501
- Views 52
- Downloads 0
HEMODIALYSIS ACCESS INDUCED DISTAL ISCHEMIA; EFFECTIVENESS OF DIFFERENT TYPES OF REVISIONAL SURGERIES.
Objectives: Hemodialysis access induced distal ischemia (HAIDI) is not a rare complication of hemodialysis access and may lead to limb loss at any time from creation. Distal Revascularization Interval Ligation (DRIL), Pr...
ROLE OF DIET IN THE MANAGEMENT OF POLYCYSTIC OVARIAN SYNDROME (PCOS).
Polycystic Ovarian Syndrome (PCOS) is hyteregenous, multisystem with Ovarianendocrinopathy in woman of reproductive age with ovarian expression of various metabolic disturbances. The prevalance of PCOS is general populat...
YIELD AND FORAGE QUALITY OF ELEPHANT GRASS IN RESPONSE TO CUTTING INTERVALS.
The aim of the study was to identify the shorter cutting intervals in relation to the production and quality of forage. Treatments consisted of two forages cutting frequencies: 12 and 8 cutting frequencies per year_1 (4...
ASSESSING THE CONSPIRACY IN THE PROCUREMENT CONTRACT OF GOVERNMENT?S GOODS AND SERVICES: ELECTRONIC PROCUREMENT CASES.
Nowadays, the enforcement of government procurement auction cannot be separated from the conspiracy practice. The improvement of procurement system is one of them done by reformation, such as the establishment of institu...
OBSTRUCTIVE SLEEP APNOEA IN CHILDREN WITH ADENOID HYPERTROPHY.
The objective of this study wasTo estimate the prevalence of Obstructive Sleep Apnoea (OSA) in children with adenoid hypertrophy using OSA screening questionnaire. This cross-sectional observational study was done in 50...