CONSEQUENCES OF DOPAMINERGIC AGONIST ASSOCIATED WITH BDNF TREATMENT ON BEHAVIORAL ALTERATIONS AND CYTOLOGICAL CHANGES IN AN EXPERIMENTAL MODEL OF PARKINSON DISEASE DUE TO MANGANESE EXPOSURE.
Journal Title: International Journal of Advanced Research (IJAR) - Year 2018, Vol 6, Issue 2
Abstract
Parkinson disease (PD) is characterized by dopaminergic (DA) neuronal loss and motor alterations; in this way, an effective therapy should protect and regenerate the DA neurons and striatal innervation. Brain-derived neurotrophic factor (BDNF) is a cell survival mediator and can improve neuronal death, and the activation of DA D3 receptors seems to protect the DA neurons. Thus, there is a synergistic relationship between BDNF and D3 receptors; which would be a neuroprotective therapy. PD animal models, although exhibit some of the features, no one mimics the alterations observed in the disease. PD-Manganese (Mn) inhalation model was used in this report since it is bilateral, non-invasive and progressive. The rats were exposed to Mn 1 hour 3 times a week, and the motor tests were conducted to measure the performance as well as the progressive damage at 3 and 6 months of exposure. Subsequently, the D3 agonist treatment (7-OH-DPAT) and BDNF gene transfection to DA neurons were co-administered, and then we evaluated its effect measuring the animals\\\\\\\' performance, and if the recovery was associated with DA neuronal and striatal dendritic spines preservation. The results showed that the animals presented PD-like motor alterations, and great DA neurons and striatal dendritic spines loss. The behavior recovery was associated with the DA neurons recuperation and with the number of dendritic spines of the striatal neurons. Thus, the BDNF overexpression in DA neurons related to the D3 receptors activation seems to be a promising approach for restoring motor alterations and DA neurons in PD.
Authors and Affiliations
M. Teresa Ibarra- Gutiearrez, Veronica Anaya- Martinez
Keywords
Related Articles
- EP ID EP278055
- DOI 10.21474/IJAR01/6501
- Views 70
- Downloads 0
ENDEMISM, ETHNO BOTANY, AND INVASIVE ALLIED SPECIES OF ODISHA- A BIO-GEO-DIVERSITY STUDY.
The aboriginal and ethnic people of Odisha in India are accustomed to living in most hostile and extreme climate under diverse meteorological conditions. The coastal state has immense rich biodiversity and possesses a ri...
KYSTE HYDATIQUE PRIMITIF ET ISOLE DE LA CUISSE: UNE LOCALISATION EXCEPTIONNELLE.
Muscular involvement with Echinococcusgranulosus is rare, even in endemic countries where the frequency is estimated to be less than 3%, particularly in the countries of the Mediterranean basin, North Africa and Latin Am...
A STUDY OF E-READINESS ASSESSMENT: THE CASE OF TWO STATE UNIVERSITIES IN LUZON.
E-Readiness plays a crucial role in the success of E-Learning initiatives with greater reason it should be conducted in an extensive approach for Higher Education Institutions to reap the benefits E-Learning has to offer...
COMPARATIVE EVALUATION OF THE EFFECT OF SALIVA SUBSTITUTE ON THE MICROHARDNESS OF THREE DIFFERENT DIRECT TOOTH COLOURED RESTORATIVE MATERIALS: AN IN VITRO STUDY.
Context: In patients usingsaliva substitute (SS) which would be a suitable aesthetic restorative material. Aims: To evaluate and compare the effect of saliva substitute on the microhardness of direct tooth coloured resto...
EPISODIC MEMORY DEFICITS: COMPARISON BETWEEN PERSONS WITH DEMENTIA OF ALZHEIMERS TYPE, MILD COGNITIVE IMPAIRMENT & HEALTHY ELDERLY INDIVIDUALS.
Episodic memory refers to the ability for recollecting an autobiographical memory of events that has occurred at a particular time and place. However, there is a dearth of episodic memory studies in Persons with Dementia...