Consequences of sperm DNA fragmentation for assisted reproductive technology
Journal Title: European Journal of Medical Technologies - Year 2013, Vol 1, Issue 1
Abstract
The possession of offspring is the most important human biological goal, which conditions the survival of the human species. The problem of the lack of offspring is a phenomenon concerning approximately 15% of married couples in Poland. In a half of the cases, the causative agent is the male factor infertility problem. It is considered that in approximately 20% of patients with idiopathic infertility, and elevated level of sperm DNA fragmentation may be the cause of failure in reproduction. High levels of sperm DNA fragmentation have also been associated with decreased oocyte fecundation, embryo quality and pregnancy rate. The quality of the genetic material carried in male sperm becomes a prognostic factor in the area of the effectiveness of treatment of an infertile couple, bearing a healthy child, as well as the risk of contracting cancer in the future generations. Present data on the consequences of sperm DNA fragmentation (SDF) for reproduction are scarce and, in many ways, inconsistent. The differences in the study conclusions might result from the different methods used to detect SDF, the study design and the inclusion criteria. Consequently, it is difficult to decide whether SDF testing should be carried out in fertility assessment and assisted reproductive technology (ART). It is clear that there is an urgent need for the standardization of the methods and the need for additional clinical studies on the impact of SDF on ART outcomes.
Authors and Affiliations
Artur Wdowiak
Keywords
Related Articles
- EP ID EP216022
- DOI -
- Views 40
- Downloads 0
Mini glide-arc plasma reactor for biological decontamination
Gliding-arc micro-reactors are used to generate non-thermal plasma. The aim of the work was to develop a compact plasma device for biological decontamination, which would not simultaneously contribute to thermal damage o...
Zaburzenia podziałów mitotycznych w komórkach somatycznych wywołane wpływem taksolu i wyciągu z Rhodiola rosea
Wstęp. Cyklem komórkowym nazywamy ciąg zdarzeń zachodzący między dwoma kolejnymi podziałami, obejmujący podział jądra (mitoza), podział cytoplazmy (cytokineza) oraz stan między kolejnymi podziałami (interfaza), składając...
Analysis of the dose area product variable in radiography of the lumbar-sacral spine using a water phantom
Radiography is a commonly used diagnostic method. In order to detect many diseases, it is first-throw for radiologists and clinicians. In today's continuous technological progress, more attention is paid to the best poss...
Wykorzystanie metody cytometrii przepływowej w badaniu reakcji akrosomalnej ludzkich plemników
Umiejętność ludzkich plemników do wchodzenia w reakcje z dojrzałą komórką jajową jest złożonym i słabo poznanym zjawiskiem. Reakcja akrosomalna ludzkich plemników w przeciwieństwie do plemników innych ssaków jest trudna...
Zasady dotyczące dokumentowania świadczeń zdrowotnych
Dokumentacja medyczna jest niezbędna w świadczeniu kompleksowej opieki nad pacjentem. Stanowi nieodzowny element komunikacji w zespole terapeutycznym. Jest też formą kontroli procesu udzielania świadczenia zdrowotnego or...