Consequences of sperm DNA fragmentation for assisted reproductive technology
Journal Title: European Journal of Medical Technologies - Year 2013, Vol 1, Issue 1
Abstract
The possession of offspring is the most important human biological goal, which conditions the survival of the human species. The problem of the lack of offspring is a phenomenon concerning approximately 15% of married couples in Poland. In a half of the cases, the causative agent is the male factor infertility problem. It is considered that in approximately 20% of patients with idiopathic infertility, and elevated level of sperm DNA fragmentation may be the cause of failure in reproduction. High levels of sperm DNA fragmentation have also been associated with decreased oocyte fecundation, embryo quality and pregnancy rate. The quality of the genetic material carried in male sperm becomes a prognostic factor in the area of the effectiveness of treatment of an infertile couple, bearing a healthy child, as well as the risk of contracting cancer in the future generations. Present data on the consequences of sperm DNA fragmentation (SDF) for reproduction are scarce and, in many ways, inconsistent. The differences in the study conclusions might result from the different methods used to detect SDF, the study design and the inclusion criteria. Consequently, it is difficult to decide whether SDF testing should be carried out in fertility assessment and assisted reproductive technology (ART). It is clear that there is an urgent need for the standardization of the methods and the need for additional clinical studies on the impact of SDF on ART outcomes.
Authors and Affiliations
Artur Wdowiak
Keywords
Related Articles
- EP ID EP216022
- DOI -
- Views 62
- Downloads 0
Nowe metody zaopatrywania poszkodowanych na polu walki
Działalność jednostek specjalnych wojska i policji zawsze była obarczona ryzykiem odniesienia potencjalnie śmiertelnych obrażeń przez funkcjonariuszy. W przypadku wielu działań dodatkowym czynnikiem ryzyka jest znaczna l...
Concept of distinct surgical personality revisited. Personality traits and personal values as surgical specialty choice predictors
Purpose: The Distinct Surgical Personality (DSP) concept continues to arouse avid interest for two reasons, namely social prestige of the surgery and on-going development of personality diagnostic methods. The aim of the...
The analysis of an absorption rate in view of electromagnetic exposure effects exemplified by the breast cancer
The aim of the paper is to introduce numerical analysis of a specific absorption rate in a woman body, mainly in the area of the breast. The analyzed realistic numerical breast phantoms are classified according to their...
Opieka ginekologiczna wśród młodych kobiet w Polsce z zastosowaniem technologii medycznych
Celem niniejszego artykułu jest przedstawienie aktualnej sytuacji opieki ginekologicznej wśród młodych Polek. Badania wskazują, że tylko 16% Polek decyduje się na pierwszą wizytę u lekarza ginekologa w momencie rozpoczęc...
The influence of centrifugation on the course of microsporogenesis in Tradescantia bracteata (L.)
Centrifugation is one of the laboratory techniques used to separate the mixture into fractions. Microsporogenesis is a process leading to development of microspores in pollen grains. The process consists in meiotic divis...