Constitutive activity of beta-adrenergic receptors in C6 glioma cells.
Journal Title: Pharmacological Reports - Year 2005, Vol 57, Issue 5
Abstract
Alprenolol and propranolol (0.001-10 muM) significantly and concentration-dependently inhibited both isoprenaline-driven and basal (non-stimulated) cyclic adenosine monophosphate (cAMP) accumulation in the rat C6 glioma cells, showing high potency particularly in the latter condition (IC (50) values of 30 and 27 nM, respectively). In the rat cerebral cortical slices, these two tested beta-adrenoceptor antagonists inhibited the isoprenaline-evoked cAMP response, but had no effect on the nucleotide accumulation under basal (non-stimulated) conditions. The obtained results suggest that native beta-adrenoceptors occurring in C6 glioma cells may be constitutively active.
Authors and Affiliations
Paulina Sokołowska, Jerzy Nowak
Keywords
Related Articles
- EP ID EP149482
- DOI -
- Views 101
- Downloads 0
Citalopram decreases tryptophan 2,3-dioxygenase activity and brain 5-HT turnover in swim stressed rats.
Background: Selective serotonin reuptake inhibitors (SSRIs) are the most widely prescribed antidepressant class today and exert their effects by increasing synaptic concentrations of serotonin (5-HT). The forced swim tes...
MDR1 gene polymorphism in allogeenic kidney transplant patients with tremor.
P-glycoprotein (P-gp), an ATP-dependent efflux pump, is a membrane protein encoded by MDR1 gene, which demonstrates functional polymorphism. It is present in endothelial cells of the blood-brain barrier. P-gp pays a role...
A carbon monoxide-releasing molecule (CORM-3) attenuates lipopolysaccharide- and interferon-gamma-induced inflammation in microglia.
The development of carbon monoxide-releasing molecules (CO-RMs) in recent years helped to shed more light on the diverse range of anti-inflammatory and cytoprotective activities of CO gas. In this study, we examined the...
Changes in hippocampal amino acid concentrations after chronic administration of corticosterone.
The effects of acute rise in corticosterone concentration upon the levels of hippocampal glutamate (Glu) are well described. Much less is known about the effect of chronic elevation of glucocorticoids on hippocampal glut...
Imidazoline receptors in relaxation of acetylcholine-constricted isolated rat jejunum.
Since 20 years the concept of specific imidazoline receptors has remained controversial. The problem with imidazoline receptors is mostly due to their functional similarity to alpha-adrenoceptors. In this work, a pharmac...