Contents of Nineteen Chemical Elements in Thyroid Benign Nodules and Tissue adjacent to Nodules investigated using X-Ray Fluorescence and Neutron Activation Analysis
Journal Title: Open Access Journal of Pharmaceutical Research - Year 2022, Vol 6, Issue 1
Abstract
Thyroid benign nodules (TBNs) are the most common diseases of this endocrine gland and are common worldwide. The etiology and pathogenesis of TBNs must be considered as multifactorial. The present study was performed to clarify the role of some chemical elements (ChEs) in the etiology of these thyroid disorders. Thyroid tissue levels of Ag, Ca, Cl, Co, Cr, Cu, Fe, Hg, I, K, Mg, Mn, Na, Rb, Sb, Sc, Se, Sr, and Zn were prospectively evaluated in nodular tissue and tissue adjacent to nodules of 79 patients with TBNs. Measurements were performed using X-ray fluorescence and instrumental neutron activation analysis. Results of the study were additionally compared with previously obtained data for the same ChEs in “normal” thyroid tissue. It was observed that mass fractions of Ag, Cl, Co, Cr, Cu, Fe, Hg, Mn, Na, and Sc contents in “nodular” tissue were higher, while Ca and I content was lower in comparison with contents of these ChEs in normal gland. Mass fractions of Ag, Cl, Hg, Na, and Rb in “adjacent” group of samples were approximately 31, 2.7, 32, 1.6, and 1.3 times higher, respectively, than in “normal” thyroid. Contents of Cr, Fe, Sc, and Se were lower, while mass fraction of Hg and I higher in “adjacent” group of samples in comparison with nodular tissue. At that, level of I in “adjacent” group of samples was over 2 times higher than in nodular tissue and almost equals the normal value. This study provides evidence on many ChEs level alteration in nodular and adjacent to nodule tissue and shows the necessity to continue ChEs research of TBNs. The little reduced level of I content in nodular tissue could possibly be explored for differential diagnosis of TBNs and thyroid cancer.
Authors and Affiliations
Zaichick V*
Keywords
Related Articles
- EP ID EP748603
- DOI 10.23880/oajpr-16000260
- Views 45
- Downloads 0
Gender-Specific Association of Oxidative Stress with Cardiovascular Risk Factors in Diabetic Patients of Central Punjab, Pakistan
Background: The present study aims to elucidate the gender-based association of oxidative- stress with cardiovascular risk factors in type II diabetes mellitus in the people of central Punjab, Pakistan. Methods: This s...
Occurrence of Microbial Resistence in Blood Cultures in a Teaching Hospital before and after the Restrictive Measure for the Commercialization of Antimicrobials in Brazil
Bacterial resistance to antimicrobial drugs (ATM) has become a global public health problem. The collegiate board of the National Health Surveillance Agency (ANVISA) through RDC 44, published on October 26, 2010, determi...
Possible Effects of Paraoxonase 1 Q192r Polymorphism on Serum Paraoxonase Activities of a Group of Type 2 Diabetes Mellitus Patients
Paraoxonase (PON) 1 is an antioxidant enzyme a member of PON family held accountable for the protection against several diseases, exposures and xenobiotics like paraoxon. It has been shown that genetic and phenotypic cha...
Contents of Nineteen Chemical Elements in Thyroid Benign Nodules and Tissue adjacent to Nodules investigated using X-Ray Fluorescence and Neutron Activation Analysis
Thyroid benign nodules (TBNs) are the most common diseases of this endocrine gland and are common worldwide. The etiology and pathogenesis of TBNs must be considered as multifactorial. The present study was performed to...
Vanilla’s Chemistry
Among Orchidaceae, only vanilla (Vanilla planifolia Andr.) is farmed for human consumption. Mexico gave this plant to the world as a gift, and it has been utilized for many things over the years. This crop's characteris...