Contents of Nineteen Chemical Elements in Thyroid Benign Nodules and Tissue adjacent to Nodules investigated using X-Ray Fluorescence and Neutron Activation Analysis
Journal Title: Open Access Journal of Pharmaceutical Research - Year 2022, Vol 6, Issue 1
Abstract
Thyroid benign nodules (TBNs) are the most common diseases of this endocrine gland and are common worldwide. The etiology and pathogenesis of TBNs must be considered as multifactorial. The present study was performed to clarify the role of some chemical elements (ChEs) in the etiology of these thyroid disorders. Thyroid tissue levels of Ag, Ca, Cl, Co, Cr, Cu, Fe, Hg, I, K, Mg, Mn, Na, Rb, Sb, Sc, Se, Sr, and Zn were prospectively evaluated in nodular tissue and tissue adjacent to nodules of 79 patients with TBNs. Measurements were performed using X-ray fluorescence and instrumental neutron activation analysis. Results of the study were additionally compared with previously obtained data for the same ChEs in “normal” thyroid tissue. It was observed that mass fractions of Ag, Cl, Co, Cr, Cu, Fe, Hg, Mn, Na, and Sc contents in “nodular” tissue were higher, while Ca and I content was lower in comparison with contents of these ChEs in normal gland. Mass fractions of Ag, Cl, Hg, Na, and Rb in “adjacent” group of samples were approximately 31, 2.7, 32, 1.6, and 1.3 times higher, respectively, than in “normal” thyroid. Contents of Cr, Fe, Sc, and Se were lower, while mass fraction of Hg and I higher in “adjacent” group of samples in comparison with nodular tissue. At that, level of I in “adjacent” group of samples was over 2 times higher than in nodular tissue and almost equals the normal value. This study provides evidence on many ChEs level alteration in nodular and adjacent to nodule tissue and shows the necessity to continue ChEs research of TBNs. The little reduced level of I content in nodular tissue could possibly be explored for differential diagnosis of TBNs and thyroid cancer.
Authors and Affiliations
Zaichick V*
Keywords
Related Articles
- EP ID EP748603
- DOI 10.23880/oajpr-16000260
- Views 23
- Downloads 0
Pharmacovigilance - Shaping the Present and Future of Medicines
Pharmacovigilance has an important role in detecting adverse drug reactions. The success of the programme depends on the knowledge and attitude of the involved professionals. Strong Pharmacovigilance programme will help...
Natural Killer Cells: From Bone Marrow to Cytotoxic Cells
Natural killer (NK) cells are lymphoid cells, having central effector functions in immune system without previous sensitization. These cells are related to innate lymphoid cells which are characterized by lymphoid cell...
Sustained Release Multiple Unit Dosage Form for the Oral Day Delivery of Dexketoprofen Trometamol
The aim of this study was to prepare sustained release multiple unit dosage form (MUDF) for the oral day delivery of the frequently administered and the highly water soluble drug, dexketoprofen trometamol (DT). The drug...
Demographical Investigations of Iraqi Patients with Nasopharyngeal and Sinonasal Neoplasms
Introduction: Age is important risk factor for nasopharyngeal and sinonasal cancers, but data regarding whether patient age at diagnosis is related to such malignancies survival are conflicting. This population-based stu...
Ending the Ebola Virus Scourge A Case for Natural Products
We investigated the binding affinities of antiviral of ethno medicinal origin to five Ebola viral proteins by in silico molecular docking simulations. One hundred and seventy three compounds were obtained from literature...