Possible Effects of Paraoxonase 1 Q192r Polymorphism on Serum Paraoxonase Activities of a Group of Type 2 Diabetes Mellitus Patients
Journal Title: Open Access Journal of Pharmaceutical Research - Year 2017, Vol 1, Issue 4
Abstract
Paraoxonase (PON) 1 is an antioxidant enzyme a member of PON family held accountable for the protection against several diseases, exposures and xenobiotics like paraoxon. It has been shown that genetic and phenotypic changes in PON1 concentration evoke some diseases such as Diabetes Mellitus (DM). The recent studies indicated in both Type 1 and Type 2 DM patients; serum PON1 activity and concentrations are diminished. In the light of this information, we carried out this study to evaluate lipid profiles and possible relationship between PON1 activity and PON1 Q192R polymorphism in a group of Turkish Type 2 diabetic patients. Due to our experimental data, the PON activity of the patients with minor RR variant is significantly higher than patients with QQ and QR variants (p<0.01). To conclude, we observed PON1 192RR genotypes are relevant to enhanced PON activity than the other variants. This situation may be interpreted as more protective to lipid peroxidation.
Authors and Affiliations
Ates I*, Altuner D, Suzen SH, Koc GV and Karakaya A
Keywords
Related Articles
- EP ID EP745824
- DOI 10.23880/oajpr-16000122
- Views 33
- Downloads 0
Comparative Antioxidative and Antidiabetic Activities of Ficus Carica Pulp, Peel and Leaf and their Correlation with Phytochemical Contents
Objective: Globally, there is a growing interest in the use of medicinal plants because of their potential therapeutic benefits as complementary and alternative therapies. The present study is focused on the In-vitro eva...
Gender-Specific Association of Oxidative Stress with Cardiovascular Risk Factors in Diabetic Patients of Central Punjab, Pakistan
Background: The present study aims to elucidate the gender-based association of oxidative- stress with cardiovascular risk factors in type II diabetes mellitus in the people of central Punjab, Pakistan. Methods: This s...
Marine Actinomycetes the Past, the Present and the Future
In the field of exploring new natural sources for biologically active products with economic importance, the marine environment draws particular attention due to the noticeable diversity and extreme conditions; it is we...
G-Reactor at Micro-Plant
The stirrer reactor govern the industrial pharmaceutical productions up to the present, however the complex transmission systems may increase the costs exponentially with the power rates and the hermetic rector sealing....
Formulation and Evaluation of Mouth Dissolving Tablets of Amiodarone
Mouth dissolving tablets are a vital tool in keeping our children and senior population healthy. Their ease of use and accurate dosing allow advanced patient compliance and further dependable remedial goods. Super disin...