CONTRAST INDUCED NEPHROPATHY IN PATIENTS UNDERGOING ELECTIVE PCI IN A TERTIARY CARE CENTRE IN COASTAL KERALA
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 72
Abstract
BACKGROUND Contrast induced nephropathy after PCI is associated with significant morbidity and mortality after PCI. Patients undergoing PCI who had risk factors for renal compromise are at higher risk. The aim of this study was to evaluate the incidence, predictors and in-hospital outcome of contrast-induced nephropathy (CIN) after elective percutaneous coronary intervention (PCI) for stable ischaemic heart disease patients. MATERIALS AND METHODS In 630 consecutive patients undergoing ad hoc PCI, we measured serum creatinine concentration (Cr) at baseline and daily for the following three days; contrast-induced nephropathy was defined as a rise in Cr of 0.5 mg/dL. RESULTS Overall, CIN occurred in 40 (6.51%) patients. Patients who develop CIN had baseline Cr. of 1.27 ± 0.23 with mean increase in S. cr value of 0.9 ± 0.47 mg/dL. In multivariate analysis diabetes (p < 0.0001), baseline Cr. clearance < 60 mL/min (p < 0.0001), contrast agent volume > 300 mL (p < 0.0001) and complex PCIs were independent correlates of CIN. No correlation was found between development of CIN and age, HTN and smoking. CIN patients had longer hospital stay and more complicated clinical course. CONCLUSION Contrast induced nephropathy frequently complicates clinical course of patients undergoing PCI, even in patients with normal renal function. Thus, preventive strategies are needed, particularly in high-risk patients.
Authors and Affiliations
Jayaram Vasu, Cicy Bastian, Chandra Mohan, Sabith Muhammad
Keywords
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- EP ID EP265608
- DOI 10.14260/Jemds/2017/1114
- Views 63
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