Controlled Release Tablets of Zileuton by Using Gum Based and Hpmc Polymers
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2017, Vol 12, Issue 3
Abstract
The aim of the present study was to develop Controlled release formulation of Zileuton to maintain constant therapeutic levels of the drug for over 12 hrs. Sodium alginate, Guar gum and HPMC K15M were employed as polymers. Zileuton dose was fixed as 300 mg. Polymers were used in the concentration of 100, 200 and 300 mg concentration. All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits. Whereas from the dissolution studies it was evident that the formulation (F6) showed better and desired drug release pattern i.e., 98.86 % in 12 hours. It contains the natural polymer Zileuton as controlled release material. It followed zero order release kinetics mechanism.
Authors and Affiliations
Ayesha Haseena, Asfia Kauser, Faheem Unnisa Begum, Taiyaba Fatima
Keywords
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- EP ID EP389176
- DOI 10.9790/3008-1203030110
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