To Study A Formulation, Development And Optimization Of Lornoxicam 8mg Tablets
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 2
Abstract
Tablet dosage form constitutes a major portion of the drug delivery systems that are currently available. These are usually prepared with the aid of suitable pharmaceutical excipients. They may vary in appearance, size, shape, weight, hardness, thickness, disintegration and dissolution characteristics and in other aspects depending on their intended use and method of manufacturing. Tablets are manufactured primarily by either granulation or direct compression. The latter involves the compression of a dry blend of powders that comprises drugs and various excipients. The simplicity and cost effectiveness of the direct compression have positioned direct compression as an attractive alternative to traditional granulation technologies. Fast disintegrating (DT) dosage form provides an opportunity to manufacturers to extend product life cycle and to expand market. Fast disintegrating tablets have this opportunity over conventional tablets. Lornoxicam is non steroidal anti-inflammatory drug (NSAID) and used in treatment of post traumatic pains (PTP), muscular and skeletal pains, joint disorder and rheumatic arthritis (RA). Fast onset of action is required in these indications and to improve bioavailability as well. Lornoxicam fast disintegration tablets were prepared by direct compression method by using Low substitute hydroxypropylcellulose (HPC) as disintegrating agent and optimized sodium bicarbonate and calcium hydrogen phosphate, anhydrous. Independent variables were concentration of excipients used in the formulation while dependent variables were disintegration time and percent drug released. Optimized formulation, T-06, showed drug content (100.527%), disintegration time (40sec), percent drug released (102.179%). Present study demonstrated potential for rapid absorption, improved bioavailability, effective therapy and patient compliance.
Authors and Affiliations
I. Rahman1, W. Jamil2, A. Zahid, K. Farooqi4
Keywords
Related Articles
- EP ID EP383442
- DOI 10.9790/3008-1102017383
- Views 87
- Downloads 0
Antibacterial Activity of Astrotrichiliaparvifolia(J.-F. Leroy &Lescot)Leaf Extracts (Meliaceae)
This work was designed to assess the antibacterial activity of Astrotrichiliaparvifolia, a Malagasyendemic Meliaceae used in traditional medicine.Ethyl acetate and methanol extracts from leaves were tested against pathog...
A New Rp-Hplc Method Develop A New Rp-Hplc Method Development And Validation For Simultaneous Estimation Of Pyridoxine Hydrochloride And Doxylamine Succinate In Bulk Drug And Pharmaceutical Tablet Dosage Form
The Present work was to develop a simple, fast, accurate, precise, reproducible, reverse phase high performance liquid chromatographic method for simultaneous estimation of pyridoxine hydrochloride and doxylamine succina...
Retrograde Cystourethrogram Findings in Patients with Suspected Uretharal Strictures In Yenagoa, Nigeria
A retrograde cystourethrogram (RCUG) in conjunction with a voiding cystourethrogram (VCUG) or intravenous urethrogram (IVU) serve as the gold standard for the diagnosis of a urethral stricture. In this study, we reviewed...
Validation of Russell’s Viper Venom Detoxification Activity of Azadirachta indica through In Silico Method
Azadirachta indica A. Juss. (neem) is one of the Indian medicinal plants used as antidote to snake venom particularly against viper envenomation. In the present study 335 phytochemicals reported from Azadirachta indica w...
Phytochemical and Antifungal Activity of Nigeria Jatropha Multifudia Latex.
Jatropha multifudia is an ornamental plant which is employed to cure various infections in traditional medicine. The phytochemical analysis of the latex in mg/100g revealed the presence of secondary metabolites with phen...