Copper-catalyzed Ligand-Free Suzuki–Miyaura Coupling Reaction of Aryl Halides with Arylboronic Acid
Journal Title: Journal of Medicinal and Chemical Sciences - Year 2019, Vol 2, Issue 1
Abstract
A highly efficient and ligand-free approach for the Suzuki–Miyaura cross-coupling reaction of aryl halides with arylboronic acid catalyzed by CuI/Cs2CO3 in DMF has been developed. Under the described conditions, a category of aryl halides including iodides and bromides, whether electron-rich or electron-deficient, were coupled with arylboronic acid to give the target products (moderate to excellent yields). This catalytic system was less efficient in the reactions of aryl bromides as a higher reaction temperature was required to improve the yield.
Authors and Affiliations
Hua-Feng Zhang
Keywords
Related Articles
- EP ID EP491190
- DOI 10.26655/JMCHEMSCI.2019.6.7
- Views 131
- Downloads 0
Efficient and Alternative Characterization of transition aluminas (η, γ, ϴ, δ-Al2O3) Derived from Aeroxide: Application of FT-IR and SEM
Heat treatment of Aeroxide (Alu C) at 500 oC in high vacuumproduced reactive phase onaluminum oxide surface. While Aeroxide from Degussa shows a mixture of transition aluminas (γ, δ, and ϴ) phases, precise understanding...
Equilibrium and thermodynamic studies of Pb(II), Zn(II), Cu(II) and Cd(II) adsorption onto mesembryanthemum activated carbon
Adsorption of Pb(II), Zn(II), Cu(II), and Cd(II) ions onto Mesembryanthemum activated carbon in a batch experimentby taking the consideration of adsorbent particle size, initial concentration, temperature, and pH was stu...
Biosynthesis of Iron Oxide Nanoparticles by Cytoplasmic Extract of Bacteria Lactobacillus Fermentum
During the past decade, the attention of science and technology has focused on production of nanoparticles. There are various ways for synthesizing nanoparticles that are not cost effective due to power and material cons...
Solvent-Free Acylation of Alcohols, Phenols, Thiols and Amines
The hazardous and toxic nature of many solvents, in particular organic solvents that are extensively used in large scale for organic reactions have transformed a serious threat to the environment. Therefore, the design o...
Theoretical and Experimental Methods for Study of Binary mixtures viscosity at T=303.15
Molecular interactions in binary mixtures composed of a xylene and selected 1-butanol 1- pentanol, 1-hexanol, 1-heptanol and 1-octanol was investigated by measuring the viscosity at T= 303.15 K. From experimental data, v...