Corneal pharmacokinetics of the 2% diacerein eye drops between multiple administration and single administration
Journal Title: Guoji Yanke Zazhi - Year 2018, Vol 18, Issue 4
Abstract
AIM: To compare the pharmacokinetic differences of the 2% diacerein eye drops between conjunctival sac multiple administration and single administration in the cornea, and to provide the experimental basis for clinicians to use the conjunctival sac multiple administration.<p>METHODS: Male Kunming mice were randomly divided into the multiple administration group and the single administration group. The multiple administration group were given diacerein eye drop every 2min(3 times in total). The concentrations of the metabolites of diacerein in the cornea were measured by high performance liquid chromatography after given eye drop 5, 15, 30, 60, 120, and 180min. The pharmacokinetic parameters were calculated by pharmacokinetic software(DAS2.1.1). <p>RESULTS: The metabolites of diacerein, rhein, was detected in the cornea at each time point. The concentration of the metabolite of diacerein in the cornea was 318.678±40.88, 210.02±25.66, 188.83±31.74, 112.24±11.70, 90.28±22.01 and 57.67±13.71μg/g after given eye drop 5, 15, 30, 60, 120, and 180min in the multiple administration group. The concentration in the single administration group was 145.17±19.29, 97.95±10.49, 71.18±18.70, 39.11±2.44, 18.10±2.34 and 9.08±2.04μg/g respectively. The concentration of rhein in the cornea was the highest at 5min after the administration in the two groups. The concentration of the multiple administration group was higher than that in the single administration group at 5, 15, 30, 60, 120, and 180min(<i>P</i><0.01). The half-life of the drug was 0.89±0.31h in the single administration group. <p>CONCLUSION: Compared with the single administration, the conjunctival sac multiple administration has the advantages of high drug concentration and long duration. Therefor the conjunctival sac multiple administration is a more effective method to treat acute infectious corneal diseases.
Authors and Affiliations
Hong-Min Zhang
Keywords
Related Articles
- EP ID EP656091
- DOI 10.3980/j.issn.1672-5123.2018.4.08
- Views 125
- Downloads 0
Effect of calcium dobesilate combined with panretinal photocoagulation on severe non-proliferative diabetic retinopathy patients
AIM: To study the effect of calcium dobesilate combined with panretinal photocoagulation on severe non-proliferative diabetic retinopathy patients(NPDR). <p>METHODS:A total of 92 patients(184 eyes)with severe NPDR were c...
Study on phototherapeutic keratotomy for bacterial corneal lesions in rabbit
AIM: To study the effect of phototherapeutic keratectomy(PTK)on rabbit bacterial corneal ulcer model and explore the clinical potential of this method. <p>METHODS: Totally 48 eyes from all the 24 New Zealand rabbits were...
Clinical efficacy of pseudo-ginseng powder for post-vitrectomy vitreous hemorrhage in diabetic patients
AIM: To evaluate the efficacy of pseudo-ginseng power for post-vitrectomy vitreous hemorrhage in diabetic patients and provide new insight into the treatment options. <p>METHODS: Totally 32 eyes of 32 patients with post-...
Effects of scleral tunnel incision or clear corneal incision with same length of phacoemulsification
AIM: To explore the differences of clinical effects between 3.0mm scleral tunnel incision and 3.0mm clear corneal incision of phacoemulsification(Phaco). <p>METHODS: The clinical data of 114 patients with cataract(114 ey...
Study on the change of retinal thickness and choroidal thickness and correlative factors for macular edema after Ranibizumab injection
AIM: To evaluate the change of retinal thickness and choroidal thickness in patients with diabetic macular edema or retinal vein occlusion-macular edema after intravitreal Ranibizumab injection using spectral domain-opti...