Effects of Shuangdan Mingmu capsule on the expressions of VEGF in the retina of diabetic rat models
Journal Title: Guoji Yanke Zazhi - Year 2018, Vol 18, Issue 11
Abstract
AIM: To study the effects of Shuangdan Mingmu capsule on the expressions of vascular endothelial growth factor-a(VEGF-a), VEGF-b, VEGF-c in the retina of a diabetic rat model. <p>METHODS: Forty male SD rats were divided into Group A(normal group), Group B(model group), Group C(Shuangdan Mingmu group)and Group D(positive control group)10 rats(20 eyes)in each group. A rat model of diabetic retinopathy was established by one-time tail vein injection with STZ(50mg/kg). After modeling for 1wk, the rats were given medicine by gavage. After gavage for 4wk rats were sacrificed, and the expressions of VEGF-a, VEGF-b, VEGF-c in the retina tissues were detected by immunohistochemical method. <p>RESULTS: After gavage for 4wk the average gray values of VEGF-a, VEGF-b and VEGF-c protein in the retina of model group, Shuangdan Mingmu group and positive control group were lower than those of the normal group, and the average optical density were higher than those of the normal group. There was a significant difference between the model group and the normal group(<i>P</i><0.01). The average gray values of VEGF-a, VEGF-b and VEGF-c expression in Shuangdan Mingmu group and positive control group were higher than those in the model group(<i>P</i><0.05)and the average optical density value were lower than those in the model group.(<i>P</i><0.01). <p>CONCLUSION: Shuangdan Mingmu capsule could significantly reduce the expressions of VEGF-a, VEGF-b,VEGF-c in the retina and had a certain protective effect on the retina of rats in the diabetic retinopathy model.
Authors and Affiliations
Jun Peng
Keywords
Related Articles
- EP ID EP519478
- DOI 10.3980/j.issn.1672-5123.2018.11.03
- Views 126
- Downloads 0
Prevalence and related factors of dry eye in primary school pupils in Lanzhou
AIM:To investigate the prevalence and related factors of dry eye in primary school pupils in Lanzhou, Gansu Province.<p>METHODS: From October to November 2016, 1 347 pupils in two primary schools in Lanzhou, Gansu Provin...
Measurement of RNFL thickness in the normals and open angle glaucoma patients by OCT
AIM: To investigate the retinal nerve fiber layer thickness(RNFL)in normal subjects and primary open angle glaucoma(POAG)patients by optical coherence tomography(OCT), and to provide a theoretical basis for the diagnosis...
Comparison of central corneal thickness measurements by PachPen ultrasonic pachymetry and the other two optical measuring instruments
AIM:To compare the similarities and differences of central corneal thickness(CCT)measured by different devices, so as to provide a safe, effective, simple and accurate method for measuring corneal thickness. <p>METHODS:...
Establishment and assessment of cataract surgery in Day-care Unit at northwest of China
AIM: To describe the protocol and economic cost of the Day-care Unit cataract surgery procedure in northwest of China.<p>METHODS: Patients who received phacoemulcification and intraocular lens implantation in both Day-ca...
Effect of microRNA-155 on the pathogenesis of primary open angle glaucoma
microRNA is specifically expressed in ocular tissues and plays a unique role in ocular tissues. microRNA-155 regulates a variety of signaling pathways, affects the expression of the corresponding protein, then leads to t...