Effects of Shuangdan Mingmu capsule on the expressions of VEGF in the retina of diabetic rat models

Journal Title: Guoji Yanke Zazhi - Year 2018, Vol 18, Issue 11

Abstract

AIM: To study the effects of Shuangdan Mingmu capsule on the expressions of vascular endothelial growth factor-a(VEGF-a), VEGF-b, VEGF-c in the retina of a diabetic rat model. <p>METHODS: Forty male SD rats were divided into Group A(normal group), Group B(model group), Group C(Shuangdan Mingmu group)and Group D(positive control group)10 rats(20 eyes)in each group. A rat model of diabetic retinopathy was established by one-time tail vein injection with STZ(50mg/kg). After modeling for 1wk, the rats were given medicine by gavage. After gavage for 4wk rats were sacrificed, and the expressions of VEGF-a, VEGF-b, VEGF-c in the retina tissues were detected by immunohistochemical method. <p>RESULTS: After gavage for 4wk the average gray values of VEGF-a, VEGF-b and VEGF-c protein in the retina of model group, Shuangdan Mingmu group and positive control group were lower than those of the normal group, and the average optical density were higher than those of the normal group. There was a significant difference between the model group and the normal group(<i>P</i><0.01). The average gray values of VEGF-a, VEGF-b and VEGF-c expression in Shuangdan Mingmu group and positive control group were higher than those in the model group(<i>P</i><0.05)and the average optical density value were lower than those in the model group.(<i>P</i><0.01). <p>CONCLUSION: Shuangdan Mingmu capsule could significantly reduce the expressions of VEGF-a, VEGF-b,VEGF-c in the retina and had a certain protective effect on the retina of rats in the diabetic retinopathy model.

Authors and Affiliations

Jun Peng

Keywords

Related Articles

Efficacy of 23G intra-infusion-assisted scleral buckling on spherical retinal detachment

AIM: To observe the treatment effect and discuss availability of spherical retinal detachment by 23G intra-infusion-assisted scleral buckling. <p>METHODS: Twenty-one eyes were randomly selected from in-patients with rheg...

Corneal pharmacokinetics of the 2% diacerein eye drops between multiple administration and single administration

AIM: To compare the pharmacokinetic differences of the 2% diacerein eye drops between conjunctival sac multiple administration and single administration in the cornea, and to provide the experimental basis for clinicians...

Effects of 17-beta estradiol and tamoxifen in chronic ocular hypertension mouse model

AIM: To explore the modulation effects of 17-β estradiol(E2)and tamoxifen(TAM)in chronic intraocular hypertension mouse model. <p>METHODS: We performed anterior chamber injection of magnetic beads to induced chronic ocul...

Mechanism and effect of H<sub>2</sub>S on oxidative stress in diabetic cataract rats

AIM: To explore the effect of hydrogen sulfide(H<sub>2</sub>S)on oxidative stress in diabetic cataract rats and its mechanism. <p>METHODS:SD rats were randomly divided into control group, diabetic group, low-dosage NaHS-...

Retinal morphology and expression of Bcl-2, Bax and VEGF in early diabetic rats

AIM: To investigate the expression and significance of B-cell lymphoma factor(Bcl-2), Bcl2-Associated X protein(BAX)and vascular endothelial growth factor(VEGF)in the retina of early diabetic rats. <p>METHODS: An early d...

Download PDF file
  • EP ID EP519478
  • DOI 10.3980/j.issn.1672-5123.2018.11.03
  • Views 127
  • Downloads 0

How To Cite

Jun Peng (2018). Effects of Shuangdan Mingmu capsule on the expressions of VEGF in the retina of diabetic rat models. Guoji Yanke Zazhi, 18(11), -. https://europub.co.uk/articles/-A-519478