Correction of Serum Leptin after Successful Kidney Transplantation
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2014, Vol 4, Issue 9
Abstract
Introduction: Serum leptin levels are increased in chronic kidney disease (CKD) patients primarily due to decreased clearance by kidneys. As leptin is a 16 Kda protein, it is also not cleared even by dialysis using conventional dialyzers or by continuous ambulatory peritoneal dialysis (CAPD). Studies have shown that elevated leptin levels are corrected after successful renal transplantation. With this intention, we determined if restoration of renal function with kidney transplantation can reduce serum leptin concentration in CKD patients. Materials and Methods: A total of 21 Patients undergoing living donor kidney transplantation were studied. There were 13 men and 8 women, from 16 to 45 years of age. All patients were receiving Hemodialysis prior to transplant. All patients received triple immunosuppressant therapy after the surgery. There were no graft rejections. Blood samples were collected under fasting conditions before and 6 days after transplantation. Results: The mean age of the patients was 28.38±9.38 years. Pre transplantation leptin concentration was 9.96 + 3.48 ng/ml and this decreased to 4.07±1.7 ng/ml within six days of transplantation (p<0.0001). However there was no concomitant change in Body Mass Index (BMI) as the follow-up was too short. Plasma Creatinine level declined from 7.5±1.6 mg/dl to 1.1±0.7 mg/dl within six days after transplantation. Conclusion: Successful renal transplantation immediately reduces serum leptin levels along with serum creatinine. The reduction in serum leptin levels after renal transplantation is likely due to reversal of renal function. Neither pre nor post transplant plasma Leptin levels correlated significantly with BMI in our study.
Authors and Affiliations
Praveen Kumar Kolla, Madhav Desai, Ram Mohan Pathapati, Sujith Tumkur Rajashekar, K. Ramalingam
Keywords
Related Articles
- EP ID EP349032
- DOI 10.9734/BJMMR/2014/5598
- Views 75
- Downloads 0
Assessment of Hospital Physicians' Knowledge, Awareness, Attitude and Practice of Reporting Adverse Drug Reactions in Jeddah, Saudi Arabia
Background: Adverse drug reactions (ADRs) are an important cause of morbidity and mortality around the world. Spontaneous reporting of ADRs is considered an essential component of successful pharmacovigilance (PV). Physi...
Why Endometriosis Causes Infertility?
Endometriosis is a common disorder of reproductive age group, defined as the presence of endometrial glands and stroma outside the lining of the uterus. The disease carries enormous medical and economic burden on the soc...
Left Ventricular Noncompaction: A Rare Cause of Heart Failure in a HIV Patient
Background: Heart failure in patients with human immunodeficiency virus (HIV) is often from dilated cardiomyopathy as a result of HIV itself, drug myotoxicity, secondary infections, or drug-induced atherosclerosis. Left...
Association between Perceived Social Support and Postpartum Depression in Turkey
Aims: The purpose of this study was to find out the association between perceived social support and postpartum depression. Study Design: This study was a cross-sectional study. Place and Duration of Study: The cross-s...
Gastrointestinal Stromal Tumors: Experience from a Single Surgical Unit
Background: Gastrointestinal stromal tumors (GISTs) are rare tumors, but comprise the most common mesenchymal neoplasms of the gastrointestinal (GI) tract. We report a clinical series of abdominal GIST and discuss the d...