Correlates of adherence and utilization of Isoniazid preventive therapy in HIV patients
Journal Title: Journal of Microbiology and Infectious Diseases - Year 2015, Vol 5, Issue 2
Abstract
Objective: Isoniazid (INH) is given to individuals with latent infection of tuberculosis in order to prevent progression to active disease. It is important to understand factors associated with non-adherence to prophylactic Isoniazid. This study aimed to identify correlates of adherence and utilization of Isoniazid in HIV positive patients and to explore the opinions of patients and health care providers. Methods: Participants eligible for the study were 403 randomly selected HIV positive individuals taking INH on follow up in Yekatit 12 hospital. Adherence was measured by self-report of INH tablets taken for past 3, 7 and 30 days. In depth interview was also conducted on recruited patients and health professionals. Results: Adherence to INH was 94% for last 7 days. INH related common side effects were reported by 142 participants (35.2%) and only 53 (13.2%) discontinued. The odds of adherence was 104, 7.7 and 34.8 [95% Confidence Interval (18.7, 582.6), (2.6, 22.9) and (4.4, 272.6)] times higher among those patients who did not have jaundice, skin rash and seizure compared to those who developed, respectively. Conclusion: The prevalence of adherence to INH in Yekatit 12 hospital was better than other local and African studies and the reasons for poor adherence was strongly associated with occurrence of jaundice, skin rash and seizure. Comprehensive care and support, sustainable drug supply and evaluation of side effects are recommended. J Microbiol Infect Dis 2015;5(2): 45-50 Key words: Tuberculosis; HIV; adherence, Isoniazid, reventive therapy, side effects
Authors and Affiliations
Yitagesu Getachew, Wubegzier Mekonnen
Keywords
Related Articles
- EP ID EP89797
- DOI 10.5799/ahinjs.02.2015.02.0175
- Views 188
- Downloads 0
Isolated testicular tuberculosis masquerading as a testicular tumor
Tuberculosis is a major cause of morbidity and a persisting public health problem in the developing countries. Testicular tuberculosis particularly in isolated form is extremely rare. We report an unique case of testicul...
Cerebellar involvement that occurred during treatment of Legionella pneumonia: A case report
Legionnaires’ disease can appear with different levels of severity. A case of a previously healthy lady with communityacquired pneumonia who progressed to severe acute respiratory distress syndrome and developed cerebel...
Kolistin dirençli Acinetobacter baumannii ’ye bağlı sağlık bakımı ile ilişkili bir pnömoni vakası
Yetmiş sekiz yaşındaki erkek hasta ensefalopati tanısı ile nöroloji bölümüne yatırıldı. Ventilatör ilişkili pnömoni (VİP) nedeniyle başlanan imipenem tedavisinin 13. gününde fizik muayene, laboratuar ve radyolojik bulgul...
Kızamık; Yeniden Ortaya Çıkan Bir Hastalık
Amaç: Çalışmanın amacı bulaştırıcılığı yüksek ve ağır komplikasyonlarla seyreden viral bir enfeksiyon hastalığı olan kızamığa dikkat çekmektir. Yöntemler: Ocak 2013- Şubat 2014 tarihleri arasında Erciyes üniv...
Nasal Carriage Frequency of Staphylococcus aureus According to Education Years of Medical Students
ABSTRACT Objective: Nasal carriage of Staphylococcus aureus (NCSa) is one of the most important risk factors for nosocomial infection. Although there are numerous studies concerning NCSa frequency among medical staff, st...