Correlates of adherence and utilization of Isoniazid preventive therapy in HIV patients
Journal Title: Journal of Microbiology and Infectious Diseases - Year 2015, Vol 5, Issue 2
Abstract
Objective: Isoniazid (INH) is given to individuals with latent infection of tuberculosis in order to prevent progression to active disease. It is important to understand factors associated with non-adherence to prophylactic Isoniazid. This study aimed to identify correlates of adherence and utilization of Isoniazid in HIV positive patients and to explore the opinions of patients and health care providers. Methods: Participants eligible for the study were 403 randomly selected HIV positive individuals taking INH on follow up in Yekatit 12 hospital. Adherence was measured by self-report of INH tablets taken for past 3, 7 and 30 days. In depth interview was also conducted on recruited patients and health professionals. Results: Adherence to INH was 94% for last 7 days. INH related common side effects were reported by 142 participants (35.2%) and only 53 (13.2%) discontinued. The odds of adherence was 104, 7.7 and 34.8 [95% Confidence Interval (18.7, 582.6), (2.6, 22.9) and (4.4, 272.6)] times higher among those patients who did not have jaundice, skin rash and seizure compared to those who developed, respectively. Conclusion: The prevalence of adherence to INH in Yekatit 12 hospital was better than other local and African studies and the reasons for poor adherence was strongly associated with occurrence of jaundice, skin rash and seizure. Comprehensive care and support, sustainable drug supply and evaluation of side effects are recommended. J Microbiol Infect Dis 2015;5(2): 45-50 Key words: Tuberculosis; HIV; adherence, Isoniazid, reventive therapy, side effects
Authors and Affiliations
Yitagesu Getachew, Wubegzier Mekonnen
Keywords
Related Articles
- EP ID EP89797
- DOI 10.5799/ahinjs.02.2015.02.0175
- Views 189
- Downloads 0
An Audit of Staphylococcus aureus Bacteraemia Treatment in a UK District General Hospital
Objective: Recent guidelines from Healthcare Improvement Scotland recommend that uncomplicated Staphylococcus aureus bacteraemia (SAB) be treated with effective antibiotics for at least 14 days. This audit aimed to see w...
BOS’tan izole edilen pnömokok suşlarında penisilin direncinin artışı: Bir eğitim hastanesinden 15 yıllık tecrübe
Amaç:Son yıllarda pnömokok bakterilerine direncin değerlendirilmesinde ve eşik değerlerinde büyük değişimler meydana geldi. Bu değişimler ışığında hastanemizde 1997-2011 yıllarında beyin omurilik sıvısı (BOS) örneklerind...
Prematüre yenidoğanda sağ ventrikülde kandida miçetoma ile mantar endokarditi
Prematür yenidoğanlarda mantar miçetoma nadirdir ve sıklıkla mortaliteyle sonuçlanır. Olguların çoğunda tanı postmortem konulur. Burada Candida albicans ile kan dolaşımı enfeksiyonu gelişen, ardından endokardit ve miçeto...
Kızamık; Yeniden Ortaya Çıkan Bir Hastalık
Amaç: Çalışmanın amacı bulaştırıcılığı yüksek ve ağır komplikasyonlarla seyreden viral bir enfeksiyon hastalığı olan kızamığa dikkat çekmektir. Yöntemler: Ocak 2013- Şubat 2014 tarihleri arasında Erciyes üniv...
Hepatit C virüs enfeksiyonu olan hastada boceprevir ve amlodipin ilaç etkileşimi: Kardiyovasküler Takip
Boceprevir, Hepatit C virüs (HCV) enfeksiyonunun tedavisinde peginterferon ve ribavirin ile kombine edilerek kullanılan NS3/4A HCV proteaz inhibitörüdür. Boceprevir, büyük çoğunlukla sitokrom P450 ilişkili oksidasyon ve...