Correlation between Body Mass Index (BMI) and Waist Circumference (W.C) With Urine Albumin Excretion in Non- Diabetic Obese Subjects - A Cross Sectional Study
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 3
Abstract
Recent studies indicate that obesity per se may have a detrimental effect on the kidneys and contribute in the long term to the development and progression of Chronic kidney disease (CKD) as central body fat distribution is directly associated with progressive renal damage. The role of Urine albumin creatinine ratio (UACR) as an early predictor of CKD risk in non-diabetic, obese individuals is poorly understood. The present study is undertaken to correlate the body mass index (BMI) and Waist circumference (WC) with urine albumin excretion in non-diabetic obese subjects. The cross-sectional study included 144 non-diabetic obese patients with a mean age of 31.94 +/- 11 9, BMI of 36.78+/- 5.15 and a mean HbA1c of 5.64+/- 0.4476.They had mean UACR 8.49 mg/gm+/- 9.42 estimated by UACR in mg / g = Urine albumin (mg / dl) ---------------------------------- Urine creatinine (g / dl). Calculated value is obtained from Beckman coulter Olympus AU 2700. Pearson correlation coefficient analysis revealed significant correlation between UACR and W.C (r=0.302(P < 0.001) and between UACR and BMI r = 0.23 (P =0.006). Multiple regression analysis showed significant predictors of UACR as W.C (p = 0.014) and FPG (p = 0.040). A targeted early monitoring of non-diabetic obese individuals with a simple urine estimation of UACR could potentially identify those at risk of progression to CKD.
Authors and Affiliations
Sujaya. P, Arun Menon. S, Sundaram. K. R, Leela Menon. N, Gopalan. M, Jeyaseelan. N
Keywords
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- EP ID EP591663
- DOI 10.9790/0853-1603018086
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