Penetration of Moxifloxacin into Aqueous Humour and Plasma following Oral Administration among Cataract Surgery Patients
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 1
Abstract
Introduction : Endophthalmitis is one of the most serious complication following cataract surgery. Topically administered antibiotics are usually given at frequent interval starting few days before surgery to achieve desired concentration in aqueous humour for the prevention of endophthalmitis.Moxifloxacinsignificantly penetrates into aqueous humour after oral administration that may improve patient compliance. Objectives : Present study was designed to evaluate the aqueous and plasma concentrations of moxifloxacin administered orally at different time interval before cataract surgery. Methodology : Prospective study of 25 patients scheduled for cataract surgery.Patients were divided into 5 Groups (Group A, B, C, D & E) and each Group comprises of 5 patients. Single dose of oral moxifloxacin – 400 mg tablet was given to each Group at different time schedule i.e. 2, 4, 8, 12, and 18 hours before aqueous humour sampling accordingly to Group A, B, C, D & E respectively. Topical moxifloxacin eye drop ( 0.5%) - 1 drop 6 times daily for 3 days before surgery and 1 drop 4 times on the day of surgery was also given to the all subgroups for the ethical reasons.The antibiotic concentration in aqueous aspirates and plasma were determined by using HPLC. Results : Aqueous and plasma concentrations of moxifloxacin wasmaximum in Group A and least in Group E. Conclusion : Administratiuon of single dose of oral moxifloxacin increases the aqueous concentration of moxifloxacin for the prevention of post operative endophthalmitis in cataract surgery patients..
Authors and Affiliations
Sujash Halder, Rajat Kanti Biswas, Kanchan Kumar Mondal
Keywords
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- DOI 10.9790/0853-1801093236.
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