Correlation between HDL Levels & Paroxanase Activity in Serum of Patients with Type II Diabetes Mellitus
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 8
Abstract
Type 2 diabetes mellitus is a hereditary disease, which has a close correlation with development of coronary artery disease. It has been shown that the HDL-associated enzyme, paraoxonase (PON1), is responsible for prevention of the oxidation of LDL, thereby protecting against complications like coronary artery disease and myocardial infarction in patients of diabetes mellitus. So, PON1 functions as an anti-oxidant. In this study, the paraoxonase (PON1) activity was correlated with the levels of HDL in serum of the patients of type II diabetes mellitus. There were 100 patients of type II diabetes mellitus, ranging from 40 to 80 years of age. A significant positive correlation was found between serum PON1 activity and HDL cholesterol levels. It appears that this association contributes to the protection conferred by HDL, against low density lipoproteins (LDL) peroxidation and subsequent development of coronary artery disease.
Authors and Affiliations
Dr. Gurmanpreet, Dr. Ashita Sharma, Dr. Neeru Bhaskar
Keywords
Related Articles
- EP ID EP480713
- DOI -
- Views 76
- Downloads 0
To Evaluate the Prevalence of Carotid Artery Plaques in Patients of Coronary Artery Disease
Abstract: Coronary artery disease is a leading cause of mortality and morbidity in the world. India is now in the middle of a CAD epidemic with urban having CAD rates similar to overseas Indians, which is 4-fold higher t...
Pregnancy Outcome in Grandmultiparity in Modern Setting
Abstract: Antenatal, intrapartum and postpartum complications are thought to be more in grand multiparous females and this is labeled among one of high risk pregnancy group. Our aim is to find maternal and perinatal comp...
Tuberculosis in HIV: Correlation of Tuberculin Test and Radiological Presentation of Tuberculosis with CD4 Count
Fight against human immunodeficiency virus (HIV) is incomplete without addressing the problems associated with difficult diagnosis of tuberculosis in HIV-Tuberculosis co infected patients. Chest X-ray and Tuberculin test...
Ultrasonographic Evaluation of Carotid Artery Atherosclerosis in Normotensive and Hypertensive Individuals
Hypertension is an important and independent risk factor for atherosclerosis which is a major killer throughout the world. Hence, it is very important to identify initial atherosclerotic changes so that more vigorous pre...
The Study of Serum Calcium and Vitamin D Levels in Preeclampsia and Pregnancy Induced Hypertension
Abstract: Recent evidences suggest a high prevalence of calcium and vitamin D deficiencies in preeclamptic women. However, level of these parameters in pregnancy induced hypertension has not been studied thoroughly. So t...