Correlation Between Insulin Resistance and Homocysteine in Hypothyroid Patients
Journal Title: Journal of Krishna Institute of Medical Sciences University - Year 2018, Vol 7, Issue 1
Abstract
Background: Hypothyroidism has been associated with disorders of glucose and insulin metabolism involving defective insulin secretion in response to glucose, hyperinsulinemia, altered peripheral glucose disposal and insulin resistance. Assessment of insulin resistance and homocysteine may help identifying subjects at high risk of Cardiovascular Disease (CVD). Aim and Objectives: The present study was designed to assess the susceptibility of hypothyroid patients to CVD by determining the relationship between Homocysteine (HCY) and Insulin Resistance (IR). Material and Methods: One hundred patients of hypothyroidism in the age group of 18-45 years was included in this cross sectional study. Homocysteine and insulin was estimated by ELISA method. Homeostasis Model of Assessment (HOMA) which is an index for IR was used to measure insulin resistance. Results: In the present study hypothyroid patients had several fold increase in insulin levels demonstrating IR by increased HOMA index and also increased homocysteine levels which may play an important role in pathogenesis of complications of thyroid hormone. In our study there was significant positive correlation between TSH and serum insulin values r = 0.447 and also homocysteine r = 0.302. We also found positive correlation between IR and homocysteine in hypothyroid patients with r = 0.295. Conclusion: Therefore to conclude our study emphasised the importance of TSH that is positively correlated with IR and homocysteine independent of thyroid hormones. Homocysteine and IR both are associated with endothelial dysfunction and are common mediators in the pathogenesis of accelerated atherosclerosis and cardiovascular complications.
Authors and Affiliations
Manju Chandankhede, Madhur Gupta, Suresh Chari
Keywords
Related Articles
- EP ID EP255367
- DOI -
- Views 86
- Downloads 0
Mature Cystic Teratoma of the Fallopian Tube – A Rare Case Report
Primary mature teratomas of the fallopian tube are extremely rare and about 60 cases have been reported in the literature. Most of them have been discovered incidentally and none has been diagnosed preoperatively. In cas...
Preventive Effects of Enicostemma littorale Blume Extract against Dexamethasone Induced Insulin Resistance in Wistar Rats
Background: Insulin resistance is a pathological condition in which physiological levels of insulin produce only subnormal biological responses. In such instances, â cells of the pancreas produce more insulin but the cel...
Infiltrating Ductal Carcinoma Arising in Fibroadenoma and Associated Proliferative Mammary Disease in a 38 Years Old Female -A Rare Case Report
Infiltrating ductal carcinoma arising in a fibroadenoma is a rare incidental finding. Incidence is 0.002-0.0125%. Women having proliferative disease without atypia have a twofold elevation in their risk for subsequent in...
An Epidemiological Study of Cases of Urothelial Carcinoma of Urinary Bladderin a Tertiary Care Centre
Background: Urinary bladder cancer is the fourth most common malignancy in Western world. It is a heterogeneous disease with variable natural history. There is paucity of data in our country. Aims and Objectives: The pre...
Primary Cutaneous Nocardiosis of Axillary Region: A Case Report
Background: Nocardiosis is an uncommon but world-wide infection caused by several species of soil-borne aerobic bacteria belonging to the genus Nocardia. Primary cutaneous nocardiosis (PCN) is an uncommon entity. It usua...