CORRELATION OF ADIPOCYTOKINES AND OXIDATIVE STRESS IN TYPE 2 DIABETES MELLITUS AND THEIR ASSOCIATION WITH DEGREE OF INSULIN RESISTANCE.
Journal Title: International Journal of Basic and Applied Physiology - Year 2016, Vol 5, Issue 1
Abstract
Background and Objectives: Adipocytokines and Oxidative Stress are often studied in relation to various morbidities but whether these two are interrelated in causing insulin resistance in type 2 diabetes mellitus, is controversial. This study explored their association in type 2 diabetes mellitus and correlation with insulin resistance. Methods: 69 male diabetics and 30 age-sex matched non- diabetic control were studied. Fasting blood glucose, serum insulin, leptin, adiponectin and plasma MDA ( Malondealdehyde, marker for Oxidative Stress) were estimated and compared between two groups by unpaired Student’s t – test. Insulin resistance score was calculated by HOMA-IR (Homeostatic Model Assesment- Insulin Resistance) method. Correlation among the parameters was assessed by Pearsons coefficient of correlation (r- value). Results: Diabetics had higher levels of leptin, MDA , leptin- adiponectin ratio but lower adiponectin than non-diabetics. Correlation of MDA was positive with Leptin but inverse with adiponectn. Insulin reistance score was correlated positively with leptin, leptin- adiponectin ratio, MDA but negatively with adiponectin. Interpretation: Study concludes that, Oxidative Stress may lead to over production of leptin and suppress that of adiponectin and thereby result in increased leptin- adiponectin ratio which is a necessary background for insulin resistance. This is how, oxidative stress may have a positive correlation with insulin resistance in type 2 diabetes mellitus
Authors and Affiliations
Piyali Das, Subhradev Biswas, Subir Kumar Bandyopadhyay, Madhumita Manna, Gorachand Bhattacharya
Keywords
Related Articles
- EP ID EP540308
- DOI -
- Views 58
- Downloads 0
STUDY OF RELATIONSHIP BETWEEN BLOOD PARAMETERS WITH MYOCARDIAL INFRACTIONS
Background: The aim of this study was to find out the changes in blood parameters in a group of myocardial infarction patients in Jamnagar, Gujarat. Method: In this cross sectional study conducted at the medicine clinic...
AN EVALUATION OF DYNAMIC PULMONARY FUNCTION TESTS IN SICKLE CELL ANAEMIA IN RAIPUR DISTRICT, CHHATTISGARH
Background and Objectives: Sickle cell anaemia is a life-long haematological disorder characterized by red blood cells that assume an abnormal, rigid, sickle shape. It is the most widespread and numerically the most imp...
RELATION OF AGE, PARITY AND SIZE OF THE LESION TO OESTROGEN AND PROGESTERONE RECEPTOR STATUS IN PATIENTS OF BREAST CANCER
Background: Breast cancer is one of the most common cancers among women in India and abroad. Tumor markers are becoming increasingly important in breast cancer research because of their impact on prognosis, treatment and...
A COMPARATIVE EVALUATION OF RESPIRATORY INDICES IN PETROL STATION WORKERS OF AGARTALA.
The study was conducted on 32 nonsmoker healthy petrol pump workers within 20-50 years age group working in different petrol stations of Agartala with 32 age and sex matched healthy controls from general population. Pulm...
EFFECT OF UPPER BODY FAT DISTRIBUTION ON PULMONARY FUNCTIONS IN MEDICAL STUDENTS.
Background: The prevalence of obesity is increasing, and there is evidence that obesity, in particular abdominal obesity as a marker of insulin resistance, is negatively associated with pulmonary function. The mechanism...