Correlation of Blood Pressure with Serum Magnesium Levels during Treatment of Preeclampsia with Magnesium Sulphate: A Cross Sectional Study
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 12
Abstract
Magnesium sulphate is effective in the prevention and treatment of seizures of preeclampsia. Although postulated to have antihypertensive effects; its use as an antihypertensive in preeclampsia management is however yet to be established. Our study aimed to determine the relationship between serum magnesium and blood pressure levels during treatment of preeclampsia with magnesium sulphate. It is a secondary analysis of data obtained from a prospective cross sectional study, on the clinical and biochemical correlates of preeclampsia among 75 patients who were administered magnesium sulphate (MgS04) using the Pritchard protocol. The results of serum magnesium assay obtained before each dose of MgS04, were correlated with the mean arterial blood pressure (MABP), using Pearson correlation statistics. The participants were mostly admitted in the antepartum period 67/75 (89.3%), with mean gestational age of 36.4±3.0 weeks. The mean loading dose (LD)-delivery interval was 5.94±4.2hrs. Significant proteinuria was predictive of severe hypertension (95%CI 0.003-0.006, p=0.005) while significantly lower rates of severe hypertension occurred among patients who had convulsed before admission (95%CI 0.073-0.564, p=0.002, OR=0.203). No significant correlation was found between MABP and serum magnesium level before (r=0.223, p=0.054) and during treatment with magnesium sulphate [4hrs (r=0.120, p=0.321), 8hrs (r=0.064, p=0.602), 12hrs (r=0.078, p=0.526), 16hrs (r=-0.026, p=0.834), 20hrs (r=-0.027, p=0.833), 24hrs (r=-0.151, p=0.238)] respectively. Also, severe hypertension (MABP≥125mmHg) had no statistically significant relationship with serum magnesium levels throughout treatment; 4hrs (p=0.462), 8hrs (p=0.208), 12hrs (p=0.346), 16hrs (p=0.925), 20hrs (p=0.376) and 24hrs (p=0.887) respectively. While MABP demonstrated a progressive decline in slope until completion, serum magnesium levels had a sinusoidal pattern with a peak at 8hrs. The MABP was not significantly affected by magnesium sulphate administered for seizure treatment. Thus, antihypertensive drugs should be administered for blood pressure control during treatment of preeclampsia with magnesium sulphate.
Authors and Affiliations
John Osaigbovoh IMARALU, OlabisiMorebise LOTO, Franklin Inyang ANI, Isaac ADEDIJI, Abimbola AFOLABI- IMARALU
Keywords
Related Articles
- EP ID EP421598
- DOI 10.9790/0853-1712022432.
- Views 59
- Downloads 0
Correlation between Ectopic Pregnancy and Previous Tubal Ligation in Rural Medical College
Risk factors for ectopic pregnancy include: pelvic inflammatory disease, often due to chlamydia infection, tobacco smoking, prior tubal surgery, a history of infertility, and the use of assisted reproductive technology....
Corrective Osteotomy in Obafemi Awolowo University Teaching Hospitals Complex: A 15 Year Review
Background: Corrective osteotomy is performed most often to correct angular or rotational deformities in the lower limbs. Many deformities in growing children have potentials for spontaneous corrections while some will r...
Role of Ormeloxifene in Treatment of Mastalgia And Fibrocystic Breast Disease : A Study Done in Rajendra Institute of Medical Sciences
Background: Mastalgia and fibrocystic breast diseases are common in women. Ormeloxifene is a weak oestrogen receptor (ER) agonist, a strong ER antagonist (SERA) and therefore a selective ER modulator (SERM) used in the t...
Comparative Study of Lactose Intolerance in Rural and Urban Population in Bangladesh
Lactose intolerance is a common problem worldwide, especially in tropical areas. This study was carried out to see the comparison of prevalence of lactose intolerance and its symptom pattern in rural and urban areas. Fas...
Morphological And Topographical Anatomy Of Nutrient Foramina In Human Upper Limb Long Bones And Their Surgical Importance
Objectives: To study the morphology and topography of nutrient foramina and to determine the foraminal index of the upper limb longbones. Materials and Methods: The study comprised of 243 upper limb long bones, which inc...