Correlation of Computed Tomography Findings with Histopathology in Small Lung Adenocancer
Journal Title: Journal of Ankara University Faculty of Medicine - Year 2019, Vol 72, Issue 3
Abstract
Objectives: To analyse the correlation between computed tomography (CT) features and histopathological findings of small lung adenocancers using the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society Classification of Lung Adenocancer. Materials and Methods: A retrospective review of 34 nodules (size ≤2 cm) representing lung adenocancer was performed. Besides their attenuation type (solid, mixed, pure ground glass), tumours were defined as air-containing type if their vanishing ratio was ≥%50 and as solid-density type if the vanishing ratio was <%50. The correlation between CT findings (size, air bronchogram, intranodular lucencies, spiculation, lobulation, notches, pleural retraction and thickening, thickening of bronchovascular bundle) and pathological results was investigated. Tumours representing adenocancer in situ (AIS) and minimally invasive adenocancer (MIA) were investigated in one group as non-/minimally invasive adenocancer (NMIA). Results: Of the 34 nodules 23 (67.7%) were invasive adenocancer, nine (26.4%) were AIS, and two (5.9%) were MIA. Lesions diagnosed as invasive adenocancer were more often of solid-density type (19, 82.6%), and solid (13, 56.5%) or mixed nodules (10, 43.5%) whereas NMIA group lesions were more often of air-containing type (9, %81.8), and pure ground-glass (3, 27.3%) or mixed nodules (7, 63.6%) with a statistically significant difference between invasive adenocancer and NMIA group (p≤0.05). Furthermore, invasive adenocancer nodules had a larger maximum diameter (15.09±3.32 mm) than NMIA nodules (12.28±3.23 mm) (p=0.031). Thickening of bronchovascular bundle was another CT finding that was significantly more common in invasive adenocancer (p=0.024). The other CT findings showed also a higher frequency in invasive adenocancer compared to NMIA group except for intranodular lucency which was observed in both pathological groups equally. But this difference in frequency was not statistically significant (p>0.05). Conclusion: Invasive adenocancer and NMIA lesions can be differentiated by their CT features. But greater study populations are needed for further confirmation.
Authors and Affiliations
Melahat Kul, Kayhan Çetin Atasoy
Keywords
Related Articles
- EP ID EP684776
- DOI 10.4274/atfm.galenos.2019.40427
- Views 145
- Downloads 0
Increased Galectin-3 Levels Predicts Ventricular Arrhythmic Events Following ST-elevation Myocardial İnfarction
Objectives: We aimed to determine the association between Galectin-3 (Gal-3) levels and microvolt T-wave alternans (MTWA) and frequent premature ventricular complexes (PVCs) in single-vessel patients with left ventricula...
Long-term Follow-up Results of Patients with Percutaneous Endoscopic Gastrostomy and Factors Affecting Survival
Objectives: Percutaneous endoscopic gastrostomy (PEG) is a minimally invasive procedure with well-known efficacy and safety that is frequently used in patients who cannot be fed orally. In the literature, studies investi...
Evaluation of Children Diagnosed with Acute Bacterial Sinusitis: Single-center Experience
Objectives: Acute bacterial sinusitis (ABS) is among frequent infections in children. Its diagnosis is clinical unless a suspicion of complication exists. This study aimed to evaluate pediatricians’ clinical approaches t...
Accuracy and Reliability of YouTube Videos as an Information Source for Osteoporosis
Objectives: There is a little data available in the literature investigating videos related to osteoporosis in the internet media. The present study investigates the characteristics and scientific accuracy of the videos...
Effects of Hypothyroidism on Central and Peripheral Atherosclerosis in the Old Aged
Objectives: Aging is associated with an increased incidence of thyroid function abnormalities. Thyroid hormones have been shown to affect vascular hemodynamics and arterial stiffness. Arterial stiffness appears to be an...