CORRELATION OF DNA DAMAGE IN SEIZURE AND ORGAN DYSFUNCTION OF PERINATAL ASPHYXIA
Journal Title: World Journal of Pharmaceutical and Medical Research - Year 2018, Vol 4, Issue 7
Abstract
The present study was conducted to evaluate the level of DNA Damage in Seizure and Organ Dysfunction in Perinatal Asphyxia and its correlation of DNA damage and Organ dysfunction. Eighty term asphyxiated babies were included in this study in which fifty nine babies had seizure. Blood samples were collected within 24 hours of birth. Comet assay was used to detect the level of DNA damage. Oxidative stress was assessed by estimation of Serum MDA level. Seizure was found in three, four and five system with % DNA in Tail of Comet as 44.39868±6.018107, 46.02007±3.899824 and 73.19868±4.359216 respectively. MDA level in seizure was positively correlated with Mutiorgan Dysfunction (r value 0.7210). Positive correlation between % DNA in tail of comet and MOD (r value 0.8408).Therefore Comet Assay and Estimation of Serum MDA level are best Parameters to determine the level of DNA damage and oxidative stress respectively in Perinatal Asphyxia.
Authors and Affiliations
A. Manoj
Keywords
Related Articles
- EP ID EP665468
- DOI -
- Views 185
- Downloads 0
COMPARATIVE SEM EVALUATION OF ETCHING PATTERNS USING ETCHANT GEL AND SOLUTION – AN INVITRO STUDY
Background: Etching of the enamel surface improves the bond strength was first introduced by Bunocore in 1955. Over the years, a lot of developments have occurred in the etching time and the materials used. Nowadays, etc...
PREVALENCE OF METABOLIC COMPLICATIONS IN TYPE 2 DIABETES MELLITUS PATIENTS
Background: With increasing trends towards sedentary life style, obesity, diabetes mellitus, hypertension, and dyslipidaemia, the prevalence of metabolic syndrome (MetS) is rising in our country. In view of importance of...
SELECTION OF MEDICAL STUDENTS BASED ON NATURAL BUILT IN ATTRIBUTES
In most medical schools, selection tools are used to assess the cognitive abilities of the candidates. Trend is growing to use tools meant to evaluate non cognitive skills also. Therefore, a number of psychological and a...
LIPOSPHERE: A NOVAL APPROACH OF DRUG DELIVERY
Lipids usually enhance drug absorption in the gastrointestinal tract (GIT), and when formulated as nanoparticles, these molecules improve mucosal adhesion due to small particle size and increasing their GIT residence tim...
ACUTE DISSEMINATED ENCEPHALOMYELITIS OR SUBACUTE SCLEROSING PANENCEPHALITIS? A CASE REPORT
Subacute Sclerosing Panencephalitis (SSPE) is a delayed and fatal complication of measles. It is a slowly progressive encephalitis that usually occurs 6 to 10 years after measles infection, and progresses over 12 to 18 m...