CORRELATION OF DNA DAMAGE IN SEIZURE AND ORGAN DYSFUNCTION OF PERINATAL ASPHYXIA
Journal Title: World Journal of Pharmaceutical and Medical Research - Year 2018, Vol 4, Issue 7
Abstract
The present study was conducted to evaluate the level of DNA Damage in Seizure and Organ Dysfunction in Perinatal Asphyxia and its correlation of DNA damage and Organ dysfunction. Eighty term asphyxiated babies were included in this study in which fifty nine babies had seizure. Blood samples were collected within 24 hours of birth. Comet assay was used to detect the level of DNA damage. Oxidative stress was assessed by estimation of Serum MDA level. Seizure was found in three, four and five system with % DNA in Tail of Comet as 44.39868±6.018107, 46.02007±3.899824 and 73.19868±4.359216 respectively. MDA level in seizure was positively correlated with Mutiorgan Dysfunction (r value 0.7210). Positive correlation between % DNA in tail of comet and MOD (r value 0.8408).Therefore Comet Assay and Estimation of Serum MDA level are best Parameters to determine the level of DNA damage and oxidative stress respectively in Perinatal Asphyxia.
Authors and Affiliations
A. Manoj
TO DETERMINE THE KNOWLEDGE, ATTITUDE, PRACTICES ABOUT HEPATITIS-B VACCINATION AMONG THE FINAL YEAR STUDENTS IN TERTIARY HEALTH CENTRE
Background: Hepatitis B virus poses a health risk to health care workers who are in close proximity to infected individuals. Medical students are particularly high risk group due to the lack of an obligatory vaccination...
RECENT APPLICATION OF SOLVENT FREE GREEN SYNTHESIS OF SCHIFF’S BASES AND IT’S DERIVATIVES: A REVIEW
The Chemistry has wide scope for Carbon-Nitrogen bond forming reactions and upgrade from traditional towards modern synthetic and mutidisciplinary methods. The preferred interesting topic in chemistry that may benefit fr...
BILATERAL PUTAMINAL NECROSIS AND BLINDNESS GIVING LATE FINDING AFTER METHANOL INTAKE: CASE REPORT
The methyl alcohol is a clear, odorless and toxic chemical substance which is found in many products such as antifreeze, defroster solutions, paint removers, and cologne and of which taste is similar to the ethyl alcohol...
FORMULATION AND EVALUATION OF PHARMACOSOMAL GEL LOADED WITH NSAID
The design of the present research work is to formulate and Evaluate Naproxen loaded pharmacosomal gel. Naproxen loaded pharmacosomes were formulated by Ether injection method. Formulations of pharmacosomes from NF1 to N...
TUBERCULOSIS IN ICU PATIENTS
Introduction: Tuberculosis (TB) is an infectious disease that causes significant mortality and morbidity worldwide.There are still many questions about the diagnosis of TB. In this study, we evaluated the clinical and la...