CORRELATION OF HER2/NEU EXPRESSION AND HISTOPATHOLOGICAL GRADING AND STAGING OF COLORECTAL CARCINOMAS
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 60
Abstract
BACKGROUND Colorectal cancer ranks third among the most common leading causes of cancer-related mortality in the world. HER2/neu oncogene is one of four epidermal growth factor receptors. Overexpression of HER2/neu was studied in many cancer types such as breast and ovary. Its amplification is associated with poor prognosis. Most of the studies of HER2/neu expression in colorectal cancer showed wide ranges from 0 to 83%. Aim- This study was done to check the expression of HER2/neu in colon carcinoma and its correlation with the histological grades and stages. MATERIALS AND METHODS Study Subjects- 50 cases of histopathologically proven colon carcinoma satisfying inclusion and exclusion criteria. SettingDepartment of Pathology in Govt. T D Medical College, Alappuzha. Period– One and half years (January 2014-June 2015). Design– Descriptive study. Statistical Analysis- Chi square test using software SPSS version 16. RESULTS The mean age in this study was 60.04 years. Male female ratio was 1:1. Sixty percent of the tumours were from colon and all the cases were adenocarcinoma NOS. Eighty percent of the cases were grade 1 tumours and stage B was the common stage noticed. Thirty two percent of the cases showed lymph node metastasis. Only 24% of cases showed HER2/neu positivity and maximum positive cases were from grade 1 tumours. Maximum number of HER2/neu positivity was given by stage B tumours and only 4% of cases with lymph node metastasis showed HER2/neu positivity. There was no statistically significant correlation found between HER2/neu expression with grade, stage and lymph node metastasis of the tumours. CONCLUSION There was no significant correlation between HER2/neu expression and tumour stages and grades.
Authors and Affiliations
Shameem Kasthuri Ummerali, Suma Sarojini
Keywords
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- EP ID EP226812
- DOI 10.14260/Jemds/2017/953
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