Correlation of Inflammatory Marker with Glycogen Phosphorylase BB (GPBB) in Patients of Acute Myocardial Infarction
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 5
Abstract
Introduction: Acute myocardial infarction (AMI) is a significant cause of morbidity and mortality worldwide, which results from occlusion of coronary artery. Glycogen phosphorylase BB (GPBB) is a new marker invented for early diagnosis of AMI. AMI is associated with profound systemic inflammatory response and inflammatory marker C-reactive protein (CRP) has been found to increase after AMI. The objective of the present study was to investigate the correlation between inflammatory marker i.e. C-reactive protein (CRP) and cardiac marker i.e. glycogen phosphorylase BB (GPBB) in AMI patients. Material and Methods: The present study includes 150 AMI patients and 100 normal healthy individuals as controls. In all the cases and controls, GPBB levels were measured by ELISA where as CRP levels were measured by diagnostic kit supplied by ERBA. Results: The mean levels of both CRP and GPBB were significantly increased in AMI cases as compared to controls. Also, there was significant positive correlation between GPBB and CRP in AMI cases. Conclusions: The positive correlation between CRP and GPBB in AMI indicates that there occurs inflammation in acute myocardial infarction patients. Hence it is concluded that CRP is a risk marker of AMI and can be used for diagnostic purpose in patients of AMI
Authors and Affiliations
Vedika Rathore, Neelima Singh, Puneet Rastogi, Roshan Kumar Mahat
Keywords
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