Correlation of leptinemia with components of metabolic syndrome in youths: influence of obesity, gender and stage of puberty
Journal Title: Journal of Diabetes and Obesity - Year 2016, Vol 3, Issue 2
Abstract
Objective: To evaluate correlation of leptinemia with components of Metabolic Syndrome (MetS) in Moroccan youths, and effect of obesity, Blood Pressure (BP), gender and puberty stage on MetS-components. Study design: Anthropomorphic, metabolic and clinical parameters [Body Mass Index (BMI), Waist Circumference (WC), energy intake, Blood Pressure (BP), Plasma levels of lipids, leptin, Alanine-Amino Transferase (ALT), Apo-B, Uric Acid (UA), glucose, insulin and Insulin Resistance (IR) (Homeostasis-Model-Assessment (HOMA-IR) and Fcβ (intra hepatic-IR)] were determined in 82 obese and 51 non-obese, male and female youths at different stages of puberty. Results: Obesity was a major but not the only determinant of levels of leptin, BP, triglycerides, insulin, UA and ALT, and HOMA-IR, Fcβ; BMI was correlated with WC, BP and UA. Girls had higher leptin levels than boys, irrespective of obesity. Higher puberty stage was associated with higher values of BP, leptin, and ALT, irrespective of gender. Leptinemia was correlated with MetS-components: BMI, WC, BP, cholesterol, triglycerides, Apo-B, insulin, UA and HOMA-IR in all subjects; 10.8 - 16.2% of obese youths had MetS. Conclusions: Leptinemia was correlated with several MetS-components. Hyperleptinemia in youths, indicating leptin resistance and IR, could predict development of MetS and cardiovascular disease in adulthood. Early detection of MetS may be helpful in identifying those at risk for T2DM and CV disease, and preventive measures may be protect them from development of metabolic and cardiac disorders in the future.
Authors and Affiliations
Israili, Zafar H
Keywords
Related Articles
- EP ID EP417841
- DOI 10.15436/2376-0494.17.1177
- Views 85
- Downloads 0
Efficacious Approach to Integrating Health and Wellness Coaching into the Clinical Care for Weight Management: A Systematic Review and Proposal
Objectives: Current clinical obesity management is insufficient in helping patients initiate and sustain weight loss, requiring innovative and efficacious interventions. We investigated health and wellness coaching in cl...
Sonographic Appearances of the Incidentally Detected Pancreatic Varices in Patients with Portal Hypertension
Purpose: The aim of the study was to investigate the sonographic characteristics of the varices of pancreas in portal hypertension. Methods: We retrospectively reviewed the sonographic findings, case records and other di...
Effect of Obesity on the Time Required Achieving a FEO2 of 90% during Preoxygenation
An end-expiratory oxygen (FEO2) concentration > 90% is desirable prior to tracheal intubation. We hypothesized that the time required for pre oxygenation to achieve an FEO2 of 90% was related to patient Body Mass Index (...
Efficacy of laparoscopic sleeve gastrectomy on type 2 diabetes with BMI less than 35: a retrospective study
Objective: To evaluate the effectiveness of Laparoscopic Sleeve Gastrectomy (LSG) for resolving type 2 diabetes in obese patients even with BMI<35 kg/m2. Methods: A retrospective study was conducted on 90 type 2 diabetic...
Gene Polymorphisms of Cytokines IFN γ +874 (A/T), TNF Α-308 (G/A), IL-6 -174 (G/C), L’il-10 -1082(A/G), -819 (C/T) -592 (C/A), TGF-β1 +869 (T /C), +915 (G/C) in Algerian Type 1 Diabetes and Latent Autoimmune Diabetes in Adults (LADA)
Background: We aimed to investigate the association between five cytokines IFN gamma 874 A T TNF Alpha -308 G A IL-6 -174 G C L rsquo il-10 -1082 A G -819 C T -592 C A TGF- beta 1 869 T C 91...