Correlation of mean AgNOR count with the histological grade of high grade gliomas-A five year study
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 3
Abstract
Background-Staining for Nucleolar organizing regions can be utilized as a modality to grade the glial tumours.AgNOR has advantage of being simple, ease of use, low cost and its good correlation with other proliferative markers, as their frequency within nucleus are significantly higher in malignant cells than in normal cells. Objectives-To correlate the AgNOR's mean number with the histological type and grade of high grade glial tumors. Methods-257 high grade glial tumors (140 Anaplastic Astrocytomas and 145 Glioblastomas)specimens received in the Pathology Deptt. G.R Medical College Gwalior (India) was studied. Sections were stained with routine H & E stain & with AgNOR stain.All Glial tumours were categorized and graded histologically. The mean AgNOR values (mAgNOR) per nuclei were determined. Results-The average values of mean AgNOR i.e. mAgNOR/nucleus presented a linear increase with increasing grade of malignancy from 2.74 for Anaplastic Astrocytoma (GIII), to 3.58 for Glioblastoma (GIV). Conclusion- The malignancy grade of Glial tumors can be established both on histological features of the conventional stained sample and on the average number, the shape and the distribution of AgNORs within tumoral nuclei. The no. of AgNORs increased with increasing grade of malignancy .
Authors and Affiliations
Dr. Nitesh Rawat, Dr. Sudha Iyengar
Keywords
Related Articles
- EP ID EP554713
- DOI 10.9790/0853-1803052629.
- Views 66
- Downloads 0
“Knowledge and Attitude of Parents towards the First Seizure Episode in Children in Jharkhand- A Hospital Based Study.”
Seizure are one of the commonest pediatric neurological disorder.The incidence of seizure is highest i.e. 5% children experience seizure during the first 5 year of life, with a decreasing frequency in older age. Seizure...
“A Clinical Study of Abdominal Wound Dehiscence and Its Management”
Wound dehiscence is one among the most dreaded complications faced by the surgeons. By definition, dehiscence is the separation of fascial layers early in the postoperative course.Wound dehiscence is described as partial...
Surgical Removal of 38 Odontomes in A Palatomaxillary Area
Odontomas are nonaggressive, hamartomatous developmental malformations composed of mature tooth substances and may be compound or complex depending on the extent of morphodifferentiation or on their resemblance to normal...
FamilialHypercholesterolemia: Screening, Diagnosis And Management of Patients.
Familial hypercholesterolemia (FH) is a genetic disorder of lipoprotein metabolism resulting in elevated serum low – density lipoprotein cholesterol leading to increased risk for premature cardiovascular disease (CVD). T...
Primary Neuroendocrine Tumor Of The Testis: A Rare Testicular Tumor
Primary Neuroendocrine Tumors Of The Testis Are Rare And Account For Less Than 1 Percent Of The Testicular Tumors. The Cell Of Origin For The Same Is Unknown. There Have Been Only 60 Reported Cases Of Primary Net Of The...