FamilialHypercholesterolemia: Screening, Diagnosis And Management of Patients.
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 1
Abstract
Familial hypercholesterolemia (FH) is a genetic disorder of lipoprotein metabolism resulting in elevated serum low – density lipoprotein cholesterol leading to increased risk for premature cardiovascular disease (CVD). The diagnosis of this condition is based on clinical features, family history, altered lipids profiles and aided more recently by genetic testing. As the cardiovascular disease burden is dependent on the degree and duration of exposure to raised LDL- Cholesterol levels, early diagnosis, and initiation of treatment is essential. This review aims to highlight the screening, diagnosis, goals of therapy and management option in patients with FH. India ranks at high position along with other countries. During the last several years, our knowledge about possible biomarkers of familial hypercholesterolemia has increased, parallel the development of new therapeutic approaches. The search for a peripheral biomarker that could be utilized diagnostically has resulted in an extensive amount of studies that employ several biological approaches including the assessment of tissues, genomic, proteomics and metabolomics.
Authors and Affiliations
Pranali D. Shinde, Vinay. G. Patke
Keywords
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- EP ID EP575483
- DOI 10.9790/0853-1701027883.
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