CORRELATION OF (PRO)RENIN RECEPTOR AND VASCULAR ENDOTHELIAL GROWTH FACTOR EXPRESSION LEVEL IN THIRD TRIMESTER OF PREECLAMPSIA PLACENTAS
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2018, Vol 11, Issue 12
Abstract
Objective: This cross-sectional study was designed to correlate the expression of mRNA and protein of (pro)renin receptor ([P]RR) and vascular endothelial growth factor (VEGF) gene in preeclampsia placentas.Methods: We used 34 placenta tissues of normal pregnancy and 34 preeclampsia placenta tissues. Real-time polymerase chain reaction was used to measure relative expression of VEGF and (P)RR mRNAs, and protein concentration was measured using Sandwich ELISA technique.Results: VEGF mRNA relative expression of preeclampsia placenta was 2.83 times higher than the normal placenta (p=0.02). (P)RR mRNA relative expression on preeclampsia placenta was 1.7 times higher than the normal one (p=0.039). Expression of protein (P)RR and VEGF was lower on preeclampsia shown by p<0.05, R=0.441. From this research, it was considered that low protein of (P)RR and VEGF contributes to preeclampsia.Conclusion: There was a correlation between (P)RR and VEGF. It considers that there is any involvement of (P)RR on angiogenesis through VEGF expression in preeclampsia placenta.
Authors and Affiliations
Nelly Marissa, Sri Widia A Jusman, Yuditiya Purwosunu, Ani Retno Prijanti
Keywords
Related Articles
- EP ID EP605214
- DOI 10.22159/ajpcr.2018.v11i12.23173
- Views 92
- Downloads 0
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