Correlation of QTc Prolongation &COPD Severity
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 4
Abstract
Context: Cigarette smoking is a major public health problem & it is one of the most important risk factor for Chronic Obstructive Pulmonary Disease (COPD) which is the 4th leading cause of death worldwide.Apart from smoking environmental pollution mainly occupational exposure of toxic gases plays an important role in developing COPD.Hence treating COPD patients based on their severity reduces mortality & morbidity, COPD severity assessment is done based on GOLD criteria using spirometry, which has its own limitations,hence there is a need for more simple clinical parameter to assess the severity of COPD. Aim of the study: To assess the correlation of QTc Prolongation in Electrocardiogram & severity of COPD. Settings and Design:Prospective observational study Materials and Methods: This study is conducted among 100 known COPD patients who were admitted at Government Rajaji hospital, Madurai between January 2014 to September 2014, based on GOLD guidelines they were grouped in to mild, moderate & severe disease, baseline haemoglobin,oxygen saturation, electrocardiogram, echo cardiogram, non contrast CT chest done, & the correlation of QTc prolongation & COPD severity is assessed. Results: In our study, QTc prolongation greater than 450ms observed in FEV1% less than 50% and FEV1/FVC ratio less than 0.59. Hypoxia resulted in secondary polycythemia among severe and very severe COPD patients. Chronic hypoxia has resulted in all Arrhythmogenic complication related to COPD. Conclusions: Incidence of QTc prolongation is more with severe and very severe COPD. Oxygen saturation less than 90% were reported to have hypoxia, hence the chance of QTc prolongation is High. QTc interval more than 500 millisecond causes arrhythmia,there by causing sudden cardiac death. Hypoxia alters the cardiac repolarization, resulting in increase in the QTc prolongation and various ventricular arrhythmias. Duration of COPD is also a risk factor for developing arrhythmia and sudden cardiac death.
Authors and Affiliations
Dr G Jegan MD, Dr B Palani Kumar MD
Keywords
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- DOI 10.9790/0853-1604015154.
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