Correlation of Serum and Urinary Magnesium with eGFR in Chronic Kidney Disease Patients
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 6
Abstract
Aim And Objectives: The aim of our study is to correlate eGFR with serum and urinary magnesium levels in CKD patients. Material And Methods: This study is a prospective studywith total of 30 CKD patients(stages II-V) admitted in nephrology ward, males(n=21) and females(n=9), with mean age of 62.37±12.41 years. Serum urea, creatinine, magnesium and spot urine magnesiumwere estimated.eGFR was calculated by MDRD 4 variable equation. Pearson’s correlation done.P value of <0.05 is taken as significant. Results:In patients with CKD the Mean±SD of serum urea(mg/dl), creatinine(mg/dl) and magnesium(μmol/L) were 62.43±37.57, 4.35±3.5,0.92±0.38 respectively. The mean±SD of urinary magnesium and eGFR(ml/min/1.73m2 )were 2.2± 1.44,30.73±25.5respectively.A significant negative correlation was observed between eGFR and serum and urinary magnesium(r= -0.34, p=0.06, r= -0.55, p value <0.002)respectively. Conclusion:Our study shows increased magnesium levels in patients with high creatinine and low eGFR. Although serum magnesium levels are raised in higher stages of CKD but they are maintained within the normal range, this might be due to compensatory mechanisms adapted by the kidney.This may be attributed to deterioration in renal function leading to decreased excretion of magnesium and cannot be compensated any longer by increased fractional excretion of magnesium.However urinary magnesium showed stagewiseincreased excretion. More clinical research is needed to confirm and to understand.
Authors and Affiliations
Sabitha Thummala, Noorjahan. M, Priscilla Abraham Chandran
Keywords
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- EP ID EP387156
- DOI 10.9790/3008-1106064244
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