Correlation of Serum Ferritin in Type 2 Diabetes with Glyscosylated Haemoglobin and its relation after 3 months of follow up
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 8
Abstract
Background: Iron metabolism is involved with the development of diabetes. A few studies have suggested a causal relationship between high iron stores and diabetes. The patho-physiology behind this relationship is largely unknown, however, it is proposed that iron mediated free radical injury is the responsible factor. Objective: The objective of this study was to study Serum Ferritin levels in Type 2 DM patients and its relation with Glycosylated Hemoglobin (A1C) and the relation of Serum Ferritin with HbA1c level after follow up at 3 months. Method: In this observational case control study, Adults, aged > 18 years, with T2DM as per the Diagnostic criteria by the American Diabetes Association (ADA) were included. We measured FBG, PPBG, A1C, Serum Ferritin, Serum Creatinine in all the patients. Result: We enrolled 93 patients with diabetes. Mean serum ferritin of all patients was 354.22 + 22.31 ng/ml and mean A1C % of all patients was 8.41 + 0.41%. Significant correlation was found between serum ferritin and FBG levels. Patients with A1C >8.5% had significantly higher serum ferritin level (435.99 + 53.45 ng/ml) in comparison to those with A1C levels between 7.6 and 8.5% (223.59 + 16.88 ng/ml) as well as than those with <7.5% (207.98 + 6.54 ng/ml). On follow up at 3 month A1C levels changed significantly, but there was no significant change in serum ferritin level. Conclusion: We found that serum ferritin was significantly high in patients with diabetes both males and females as compared to normal population. Serum ferritin levels correlate significantly with FBG levels but not with PPBG and HbA1C. Patients with A1C>8.5% have significantly higher serum ferritin levels. During a follow-up period of 3 months of treatment, A1C level reduced signifacantly while serum ferritin levels did not fall significantly
Authors and Affiliations
Dr Manoj Kumar Mathur
Keywords
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