Correlation of Serum Hepcidin Levels with Inflammation and Iron Status in Patients with Esrd
Journal Title: PARIPEX-Indian Journal of Research - Year 2016, Vol 5, Issue 8
Abstract
Background and objectives: Hepcidin is a small, cysteine-rich cationic peptide synthesized in the hepatocyte, is upregulated in uremia, and its presence provides an explanation for why chronic kidney disease patients absorb iron poorly and develop functional iron deficiency. Recently, measurements of hepcidin in blood have been developed, and it could be more informative of iron status in CKD. The present study was done to assess serum hepcidin levels in ESRD patients and its correlation with iron status and inflammation Methods: The study included 72 individuals, 26 newly detected ESRD not on parenteral iron, 26 ESRD patients who already received prior parenteral iron or blood products, 20 healthy control subjects from September 2009 to May 2012. Renal function tests, serum iron, serum ferritin, serum transferrin along with prohepcidin levels were measured. Results : Hepcidin levels have been found to be elevated in ESRD patients. High hepcidin levels suggest presence of functional iron deficiency. There was significant correlation between levels of hepcidin and iron status with inflammatory markers.
Authors and Affiliations
Kalidindi Raja Karthik, Chandru T, Ram Prasad E, Varun Kumar B, Soudararajan P
Keywords
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