Correlation of serum malondialdehyde level with components of metabolic syndrome
Journal Title: Medpulse International Journal of Biochemistry - Year 2017, Vol 4, Issue 2
Abstract
Background: Metabolic syndrome is one of the major public health concerns and is emerging as a pandemic. oxidative stress is a hallmark of metabolic syndrome and plays a central role in the progression of the disease. Malondialdehyde is one of the most popular and reliable biomarker of oxidative stress. Aim: to evaluate the level of serum Malondialdehyde (MDA) and correlate that with the components of metabolic syndrome. Methods: A cross-sectional study was carried out. 100 individuals of 21-60 years were included of which the control group comprised 50 healthy individuals and the study groupcomprised50 metabolic syndrome patients. Evaluation of anthropometric variables, blood pressure, blood glucose levels, lipid profiles, and malondialdehyde was done. Results: The metabolic syndrome patients had significantly higher malondialdehyde as compared to control (7.81±2.10vs. 2.81±1.40μmoles/L). There was a positive correlation between WC,FBS,PPBS,TC,TGL,LDL,VLDL and MDA;WC (r =0.915[p<0.001]),Blood sugar(r =0.704[p<0.001] for FBS and r =0.562 [p<0.001] for PPBS),total cholesterol (r =. 971[p<0.001]),Triglycerides(r =0.976[p<0.001]), LDL(r =0.959[p<0.001]),VLDL(r =0.976 [p<0.001]). HDL showed significant negative correlation (r = -0.776[p<0.001]). Both systolic and diastolic blood pressure showed positive correlation with MDA((r =0.770 for SBP and r =0.688 for DBP[p<0.001]) Conclusion: Our study clearly indicates that metabolic syndrome is associated with oxidative stress. Lifestyle modifications through diet and exercise may help in reducing the incidence of metabolic syndrome by reducing the oxidative stress. Future research by interventional studies are needed to know about the benefitial effects of supplementation with antioxidants.
Authors and Affiliations
P Josephine Latha, T Rajalakshmi, R S Monish Anand
Keywords
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