Correlation of Serum Neopterin level with Complement C3, C4 in assessment of Systemic Lupus Erythematosus Activity
Journal Title: The Egyptian Journal of Hospital Medicine - Year 2018, Vol 73, Issue 5
Abstract
Background: Systemic lupus erythematosus (SLE) has a recurrent disease activity throughout the natural course of the disease. Assessment of this activity is often complex and time consuming. To date no measures have been created specifically for SLE. Studying serum neopterin and comparing it with other established parameters C3, C4 may add benefit for SLE follow up. Aim: The aim of our study is to evaluate the level of serum neopterin in patient with systemic lupus erythematosus (SLE) as a marker of disease activity and its correlation with other parameters of disease activity. Patients and methods: Seventy five subjects; 60 patients with (SLE); 30 of them are active and another 30 with no activity and 15 healthy subjects as a control group. Results: Serum neopterin was higher in the active group than the inactive group and a significant difference between the patients with SLE group than controls group was also reported. Our results shows that the mean value of serum neopterin in whole SLE patients (21.9 ng/ml) and the serum neopterin in the active and inactive groups was 33.9 ng/ml and 3.45 ng/ml respectively which were highly significant than the mean value of the control group (P<0.001). Also the differences between the three groups was highly significant (P<0.001). Conclusion: As increased serum neopterin levels were found in patients with SLE and were correlated with certain clinical and laboratory immunoinflammatory parameters then estimation of serum neopterin levels seems beneficial in the assessment of disease activity and evaluation of the efficacy of various treatment regimens used. Key words: SLE, Serum Neopterin, Lupus nephritis
Prevalence and possible risk factor of social phobia among male secondary and intermediate school students in Al-Medinah, 2016
<strong>Background: </strong>When prevalence estimated was based on the examination of psychiatric clinic samples, social anxiety disorder was thought to be a relatively rare disorder. The opposite was instead true; soci...
A Case Report of Dengue Encephalitis: An Atypical Neurologic Manifestation of Dengue Fever in Adults
<span>Dengue fever is a febrile disease caused by infection from one of the four dengue virus serotypes (DENV1, DENV2, DENV3 and DENV4). The clinical manifestations of dengue fever are broad-spectrum, ranging from asympt...
Assessment of Knowledge, Attitude and Practice of Parents about Immunization in Hail City, 2018
<strong>ABSTRACT<br />Background:</strong>Immunization has shown major preventive aspects of infectious diseases, disability and death. <strong>Objectives: </strong>Assessing the knowledge, attitude and practice (KAP) of...
The Correlation between Vitamin D and Polycystic Ovary Syndrome
<strong>Background: </strong>A deficiency of Vitamin D not only causes poor bone mineralization but also has been implicated in many other chronic diseases. Recent studies have suggested a relevance of vitamin D to repr...
Prevalence of Benign Prostatic Hyperplasia (BPH) in Saudi Patients above 40 Years Old
<strong>Background:</strong> Benign prostatic hyperplasia (BPH) is a common disorder amongst older men, and is accountable for significant disability. <strong>Objective:</strong> The aim of the study is to determine the...