Correlation of Spot Urine Protein:Creatinine Ratio with 24-hour Urinary Protein in Preeclampsia: A Cross Sectional Study
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2015, Vol 5, Issue 12
Abstract
Aims: The present study was undertaken to evaluate the diagnostic value of protein:creatinine ratio in spot voided urine sample for detection of proteinuria as compared to those of 24 hour urine sample in patients with preeclampsia, and also to determine the optimal cut-off value of protein:creatinine ratio with best sensitivity and specificity for the prediction of significant proteinuria. Study Design: Cross sectional study. Place and Duration of the Study: The study was conducted at teaching hospital in North Karnatak, India. The study was conducted from Jan 2012 to February 2013. Methods: This study was conducted on 52 preeclampsia patients. The 24 hour urine protein and random urine protein:creatinine ratio was determined. Pearson’s correlation, sensitivity and specificity were determined using 24-hour urinary protein as a gold standard for spot urine protein:creatinine ratio. Receiver operators characteristic (ROC) curve and area under curve was also determined using SPSS (11.5) software. All the results were expressed in mean±SD. Results: Fifty two preeclampsia patients participated in this study. The average 24 hour urinary protein was 1643.3±2079.5 mg/day. The spot urine protein:creatinine ratio was 1.47±1.68. There was a positive correlation between 24 hour urinary protein and spot urine protein:creatinine ratio (r = 0.86, P<0.0001). The area under the receiver operators characteristic curve for urine protein:creatinine ratio at various cut-off was 0.914 (95% confidence interval: 0.800-0.975, P<0.0001). The sensitivity and specificity was 71.5% and 100% respectively at protein:creatinine ratio cut-off of 0.66. Conclusion: The random urine protein:creatinine ratio predicts the amount of 24-hour urinary protein excretion with high accuracy. Hence it can be used as a faster diagnostic substitute for 24-hour urinary protein estimation in preeclampsia.
Authors and Affiliations
Sangappa Virupaxappa Kashinakunti, Manjula Rangappa, Gurupadappa Shantappa Kallaganada, Kavita Hiremath
Keywords
Related Articles
- EP ID EP347081
- DOI 10.9734/BJMMR/2015/14437
- Views 60
- Downloads 0
Correlation of Body Composition with Pulmonary Function in Adults
Context: General population has a wide variation in physical activities ranging from the people with sedentary lifestyle to people involved in regular physical activity; there is also variation amongst different age grou...
The Utility of Bispectral Index Monitoring in Management of Motor Evoked Potential Depression Occurring During Scoliosis Surgery under Total Intravenous Anesthesia: A Case Report
Motor evoked potential monitoring is becoming one of the gold standard monitoring performed to detect nerve injuries caused by surgical manipulation, especially motor deficits during spine surgeries, but there exist clin...
Latent Viruses, Microcompetition, Transcription Factor Deficiency and the Cause of Acute Lymphoblastic Leukemia
The cause of B-cell Acute Lymphoblastic Leukemia (B-ALL) is unknown. Some studies suggested that the cause might be a deficiency in certain transcription factors due to a genetic deletion. We would like to propose a diff...
Research Ethics Education among Graduate Students of the University of Ibadan, Southwest Nigeria
Aims: Research ethics is an integral part of graduate education in developed countries; but little is known about exposure of graduate students in Nigeria to this subject. This study aimed to document the current teachin...
Gender Differences in Dermatoses at Obafemi Awolowo University Teaching Hospitals’ Complex, Ile-Ife
Aims: The aim of this study was to determine the dermatoses associated with gender in this geographical area. Study Design: A descriptive cross-sectional survey. Place and Duration of Study: Dermatology Clinics of OAU T...