Correlation of Thyroid Hormones with Vitamin D Status in Acutely Ill Children
Journal Title: Medpulse International Journal of Biochemistry - Year 2018, Vol 6, Issue 1
Abstract
Objective: The aim of the study is to correlate thyroid function tests with vitamin D status and the existence of “Euthyroid Sick Syndrome (ESS)”, in acutely ill children. Methods: The present case-control study was conducted on 120 children from one to five year age groups. Out of which, 50 were healthy euthyroid children as controls and 70 were acutely ill children admitted in ICU were included. The serum total T3, T4, TSH and 25 (OH) D were estimated and compared to relate vitamin D status with the thyroid profile. Results: Out of the total 120 study cases, 45% were vitamin D deficient, 22.5% were vitamin D insufficient, and 32.5% had sufficient vitamin D. The prevalence of vitamin D deficiency was significantly more in ESS than euthyroid children (88.9% vs 11.1%, p<0.0001). The mean of total T3 (1.06 vs 1.55 nmol/ml, p=0.0001) and T4 (5.65 vs 8.19 μg/dl, p<0.0001) were significantly lower in ESS than euthyroid children, but there was no significant difference in TSH (2.44 vs 2.59 μU/ml, p=0.36). 25 (OH) D was significantly lower in ESS than euthyroid children (18.17 vs 41.82 ng/dl, p<0.0001). In ESS children the total T3 and T4 were positively and significantly correlated with circulating 25 (OH) D (r = 0.25; p = 0.03 and r = 0.55; p<0.0001), whereas TSH was not significantly correlated. The mean of total T3 (1 vs 1.01 vs 1.45 nmol/ml, p= 0.012) and T4 (4.99 vs 6.8 vs 7.44 μg/dl, p= 0.000) were significantly lower in vitamin D deficient ESS children. Conclusion: ESS with vitamin D deficient children has significantly low levels of thyroid hormones. Total T4 was positively correlated with vitamin D levels; hence lower serum total T4 levels with vitamin D deficiency were predictors to assess the severity and prognosis of ESS in acutely ill children.
Authors and Affiliations
Aruna Kumari Bandaru, Srinivas Reddy Gurrala, Vanumu Divya Sai
Keywords
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