Correlation of Tumor Necrosis Factor-Alpha Serumlevelsin NonAlcholic Fatty Liver Disease
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 11
Abstract
Fatty liver disease is the addition of free fatty acids in liver. This causes an increase in fat oxidation and esterification. When the oxidative stress condition in the liver exceeds the ability of anti-oxidants, it will activate stellate cells and pro-inflammatory cytokines which leads to a progressive inflammatory process. TNF-ɑ is a pro-inflammatory cytokine that experiences a significant increase in NAFLD. Method:This study was a cross-sectional study with a total of 30 NAFLD patients who came to Adam Malik General Hospital Medan,from April to September 2018. Assessment for NAFLD was done by ultrasound imaging. A univariate and bivariate(Chi-square and fisher exact test) analysis were performed using the SPSS version 22. Results:In the NAFLD group, there were 17 males (56.7%) and 13 females (43.3%). Average age of subjects was 44.57 years old. Median value of TNF-αin the NAFLD group was3.18 pg/ml and 1.72 pg/ml in the control. There is a significant difference of TNF-α levels between the NAFLD and control group (p=0.0001).Median value of blood glucose levelin NAFLD group is 150 mg/dl and 98 mg/dl in control. In a hypothesis test, there was a significant difference in blood glucose levels between the NAFLD and control groups (p=0.0001). Median value of total cholesterol, HDL, LDL and TG in NAFLD group were 251, 40, 178 and 175 pg/ml while in the control were 174, 60, 88,5, and 123pg/ml. There is a statically significant difference in lipid profile between the NAFLD and control groups (p=0.0001). For evaluating the levels of liver enzymes, the median value of ALT and AST in the NAFLD group were 31,5 and 27U/L, while in the control group was similar which was 20U/L. There is a significant difference in levels of liver enzymes between the NAFLD and control groups (p=0.0001). Conclusion: Thereweresignificantassociation between blood glucose levels, lipid profile, liver function test, TNF-ɑ level and NAFLD patient as well as its control.
Authors and Affiliations
Sahat Ericson Tampubolon, Gontar Alamsyah Siregar, Leonardo Basa Dairi
Keywords
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- EP ID EP416328
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