Correlation of VEGF and HIF-1α in breast carcinoma (an immunohistochemical study)
Journal Title: IP Journal of Diagnostic Pathology and Oncology - Year 2018, Vol 3, Issue 1
Abstract
Introduction By 2030 the incidence of breast cancer in India will increase to around 200000 per year During tumor growth angiogenesis is induced by many stimuli Reduced oxygen stimulates hypoxia induced factor 1 alpha HIF1alpha activating proangiogenic cytokines ie vascular endothelial growth factor VEGF The beststudied factor is VEGFA Overexpression of HIF promotes metastasis of cancers Higher the levels of VEGF poorer the prognosis HIF1alpha is an independent prognostic factor for an unfavorable prognosisMaterials and Methods Study was conducted on 50 cases of breast cancer specimens Histopathological typing and grading was done followed by immunohistochemistry for HIF1alpha expression Serum samples were collected for VEGF levelsObservations and Results Most patients were in the age group of 4160 years 94 of the tumors were infiltrating ductal carcinoma NOS the remaining being mucinous 4 and tubular 2 16 cases were Grade II and 34 cases were Grade III Lymph nodes were recovered in 44 cases of radical mastectomy Metastatic carcinomatous deposits were present in 26 cases Lynphovascular invasion LVI was seen in 20 cases sVEGF levels were increased in 21 cases No correlation was seen with grade of tumor whereas a positive correlation was seen with LVI and lymph node status No positive correlation was seen with HIF1alpha and all these parameters No significant correlation was seen between sVEGF levels and HIF1alphaConclusion sVEGF levels have direct relationship with LVI and lymph node status and should be taken as a poor prognostic factor HIF1alpha was increased more in high grade tumors but had no statistical significance with LVI and lymph node statusKeywords Breast cancer VEGF HIF1alpha Immunohistochemistry
Authors and Affiliations
Saumil Garg, Manas Madan, Manisha Sharma, Mridu Manjari, Sanjay Piplani
Keywords
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- EP ID EP482732
- DOI 10.18231/2581-3706.2018.0009
- Views 125
- Downloads 0
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