Correlations of NGAL with Age, Haemoglobin and Platelet Counts in Chronic Myeloid Leukemia Cases and Controls
Journal Title: International Journal of Science and Healthcare Research - Year 2018, Vol 3, Issue 4
Abstract
NGAL is one of upcoming markers in diagnosis and management of kidney diseases at an early stage. It has been correlated with haematological malignancies like CML, polycythemia vera and essential thrombocytopenia also. This study was conducted to find NGAL levels in CML cases and controls and find correlation if any with age, haemoglobin and platelet counts. Aims and objectives: To estimate the levels of NGAL in 30 CML cases and 30 healthy controls. To assess the correlation between NGAL level with Age, Hemoglobin and Platelet count of cases before and after chemotherapy. Materials and methods: 30 chronic myeloid leukaemia patients along with 30 healthy age and sex matched controls were enrolled for the study. Chemotherapy given consisted of imatinib (400 mg/day). Complete haemogram, routine biochemistry and Serum NGAL were estimated in all subjects. Serum NGAL was estimated by a commercial Enzyme Linked Immunosorbent Assay kit for human NGAL. Results and observations: Serum NGAL was significantly higher in CML patients (358.47 ± 125.65) as compared to serum NGAL in controls (44.5 ± 15.65) (p=0.001). Serum NGAL was significantly higher in CML patients (358.47 ± 125.65) before treatment as compared to serum NGAL value after treatment (85.03 ± 62.77) (p=0.001). No correlation was observed in age of controls and NGAL levels while a very weak positive correlation was found between age of cases and NGAL values (r = 0.32 post treatment and r = 0.26 pre treatment). It is also positively correlated with platelet count and this correlation is statistically significant (r=0.951, p=0.001). There is a weakly positive correlation between NGAL and hemoglobin (r=0.40, p=0.028). Conclusion: NGAL is a potential biomarker for not only kidney diseases but Chronic myeloid leukaemia. It is positively correlated with Platelet count of cases and weakly correlated with hemoglobin levels.
Authors and Affiliations
Dr. Shinky Mehta
Keywords
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