Kinetics of hallmark biochemical changes in paclitaxel-induced apoptosis

Apoptosis is associated with cascades of biochemical changes, including caspase activation, cleavage of poly-ADP-ribose polymerase (PARP), and fragmentation of genomic DNA. Knowledge of the kinetics of these changes in d...

Challenges in the transition to model-based development

Marketplace Analysis of Conjugated Estrogens: Determining the Consistently Present Steroidal Content with LC-MS

The online version of this article (doi:10.1208/s12248-015-9805-x) contains supplementary material, which is available to authorized users.

Fmoc-Conjugated PEG-Vitamin E2 Micelles for Tumor-Targeted Delivery of Paclitaxel: Enhanced Drug-Carrier Interaction and Loading Capacity

The online version of this article (doi:10.1208/s12248-014-9651-2) contains supplementary material, which is available to authorized users.

Population Pharmacodynamic Parameter Estimation from Sparse Sampling: Effect of Sigmoidicity on Parameter Estimates

The objective of this stimulation study was to evaluate effect of simoidicity of the concentration–effect (C–E) relationship on the efficiency of population parameter estimation from sparse sampling and i...