Could Advanced Glycation End Products Explain the Poor Response to Controlled Ovarian Hyperstimulation in Obese Women?
Journal Title: Journal of Endocrinology and Diabetes - Year 2016, Vol 3, Issue 2
Abstract
Obesity, a worldwide pandemic, adversely impacts ovarian function. The pro-inflammatory Advanced Glycation End Products (AGEs) and their cell membrane Receptors for AGEs (RAGE) are elevated in the serum and tissues of obese women, respectively. Recent data have shown that AGEs contribute to alterations in the ovarian microenvironment. This review presents and summarizes important clinical and experimental studies pertaining to the role of the AGE-RAGE system in obesity-related ovarian dysfunction. It also discusses the role of the anti-inflammatory soluble Receptor for AGEs (sRAGE) in ovarian function and its changes in obesity and following unhealthy dietary habits. Data to date demonstrated that the AGE-RAGE system affects granulosa cell function and oocyte meiosis. Follicular fluid AGEs and sRAGE have been related to in vitro fertilization outcome. Thus data suggest that obesity-related alterations in the AGE-RAGE system and changes in circulating sRAGE level could potentially compromise ovarian response to controlled ovarian hyperstimulation and could adversely impact oocyte competence and ultimately fertility outcome. Finally, there is a critical need to unveil the mechanistic actions of the AGE-RAGE system at the level of the oocyte and its surrounding granulosa and theca cells in order to better improve ovarian response to controlled ovarian hyperstimulation in obese women.
Authors and Affiliations
John J Zhang, Zaher Merhi
Keywords
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- EP ID EP333421
- DOI 10.15226/2374-6890/3/2/00146
- Views 105
- Downloads 0
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